2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Ladiratuzumab vedotin

Ladiratuzumab vedotin  (Synonyms: SGN-LIV1A)

目录号: HY-P99683

摩尔计算器

Ladiratuzumab vedotin (SGN-LIV1A) 是一种 LIV-1 靶向的抗体药物偶联物 (ADC) (IC50: 5.6 nM)。Ladiratuzumab vedotin 由人源化 IgG1 单克隆抗体、MMAE 和蛋白酶-可切割型连接子组成。Ladiratuzumab vedotin 可以驱动免疫原性细胞死亡 (ICD) 以引发免疫反应。Ladiratuzumab vedotin 可用于乳腺癌研究。

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Ladiratuzumab vedotin Chemical Structure

Ladiratuzumab vedotin Chemical Structure

CAS No. : 1629760-29-7

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Ladiratuzumab vedotin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ladiratuzumab vedotin (SGN-LIV1A) is a LIV-1 targeting antibody drug conjugate (ADC) (IC50: 5.6 nM for LIV-1). Ladiratuzumab vedotin consists of humanized IgG1 monoclonal antibody, MMAE and a protease-cleavable linker. Ladiratuzumab vedotin can drive immunogenic cell death (ICD) to elicit an immune response. Ladiratuzumab vedotin can be used for research of breast cancer[1][2][3][4].

体外研究
(In Vitro)

Ladiratuzumab vedotin (LIV-1+ 细胞) 通过 ATF6 的激活以及 IRE1 和 eIF2a 的磷酸化激活内质网应激反应[3]。
Ladiratuzumab vedotin (LIV-1+ 细胞) 将 ATP 和 HMGB1 释放到上清液中 (ICD 标志)[3]。
Ladiratuzumab vedotin (0-100 ng/mL) 对 MCF-7 细胞显示出细胞毒活性[4]。
Ladiratuzumab vedotin (1 μg/mL，24 小时) 内化、运输到溶酶体，并破坏 MCF-7 细胞中的微管网络[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ladiratuzumab vedotin 相关抗体:

Cell Viability Assay[4]

Cell Line: MCF-7
Concentration: 0-100 ng/mL
Incubation Time: 96 h
Result: Inhibited cell viability with an EC50 value of 6.3 ng/mL.
体内研究
(In Vivo)

Ladiratuzumab vedotin (3 mg/kg，腹腔注射，每 4 天一次) 在 MCF-7 乳腺癌细胞异种移植模型中导致肿瘤消退[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7 breast cancer cell xenograft model[4]
Dosage: 3 mg/kg
Administration: i.p., every 4 days
Result: Delayed tumor growth.
Animal Model: BALB/C mice (PK assay)[4]
Dosage: 3 mg/kg
Administration: i.v., single
Result: Showed a terminal half-life of 6.8 days.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ladiratuzumab vedotin 相关分类

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Keywords:

Ladiratuzumab vedotin1629760-29-7SGN-LIV1AAntibody-Drug Conjugates (ADCs)Antibody-Drug ConjugatesBreast cancerMCF-7ER stressICDimmune responselysosomeInhibitorinhibitorinhibit

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