2. Protein Tyrosine Kinase/RTK
  3. Src
  4. LCB 03-0110

LCB 03-0110 是一种噻吩并吡啶衍生物，是一种有效的泛盘状蛋白结构域受体/c-Src 家族酪氨酸激酶抑制剂。LCB 03-0110 通过抑制成纤维细胞和巨噬细胞活化来抑制疤痕形成。

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LCB 03-0110 Chemical Structure

LCB 03-0110 Chemical Structure

CAS No. : 1228102-01-9

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规格 价格 是否有货 数量
1 mg ￥2210
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of LCB 03-0110:

LCB 03-0110 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

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Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LCB 03-0110, a thienopyridine derivative, is a potent pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor. LCB 03-0110 suppresses scar formation by inhibiting fibroblast and macrophage activation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
164 nM
Compound: 13, LCB-03-0110
Inhibition of human DDR1b expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
Inhibition of human DDR1b expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
[PMID: 25569119]
HEK293 IC50
164 nM
Compound: 6, LCB 03-0110
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR1 expressed in HEK293 cells by Western blotting analysis
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR1 expressed in HEK293 cells by Western blotting analysis
[PMID: 23521020]
HEK293 IC50
171 nM
Compound: 13, LCB-03-0110
Inhibition of human DDR2 expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
Inhibition of human DDR2 expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
[PMID: 25569119]
HEK293 IC50
171 nM
Compound: 6, LCB 03-0110
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR2 expressed in HEK293 cells by Western blotting analysis
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR2 expressed in HEK293 cells by Western blotting analysis
[PMID: 23521020]
体外研究
(In Vitro)

LCB 03-0110 抑制转化生长因子 β1 和 I 型胶原诱导的原代真皮成纤维细胞的增殖和迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LCB 03-0110 相关抗体:
体内研究
(In Vivo)

LCB 03-0110 可抑制愈合伤口中肌成纤维细胞和巨噬细胞的积累，并减少兔耳伤口闭合后肥厚性疤痕的形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

417.52

Formula

C24H23N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LCB 03-0110 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LCB 03-01101228102-01-9SrcInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
LCB 03-0110
目录号：
HY-110367A
需求量：

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