2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Src Apoptosis
  4. Lck-IN-2

Lck-IN-2 (compound 12a) 淋巴细胞特异性蛋白酪氨酸激酶 (Lck) 抑制剂，IC50 是 10.6 nM。Lck-IN-2 对结肠癌细胞具有活性，GI50 值为 0.24-1.26 μM。Lck-IN-2 在 Colo201 细胞中发挥凋亡 (apoptosis) 作用。

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Lck-IN-2 Chemical Structure

Lck-IN-2 Chemical Structure

CAS No. : 2615173-24-3

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Lck-IN-2 相关抗体

Top Publications Citing Use of Products

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Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lck-IN-2 (compound 12a) is an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck) with IC50 of 10.6 nM. Lck-IN-2 reveals efficacy in colon cancer cells with GI50s of 0.24-1.26 μM. Lck-IN-2 exhibits an apoptotic effect in Colo201 cells[1].

IC50 & Target

Lck

10.6 nM (IC50)

体外研究
(In Vitro)

Lck-IN-2 以剂量依赖的方式抑制人结肠癌细胞 Colo201 中 Lck 磷酸化，并且诱导细胞凋亡[1]。
Lck-IN-2 在多种癌细胞中展现出抗增殖活性，GI50 值为 0.01-8 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lck-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: Colo201
Concentration: 0-10 μM
Incubation Time:
Result: Reduced the Lck phosphorylation and increased levels of cleaved PARP in dose-dependent manner
分子量

596.64

Formula

C31H32N8O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lck-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lck-IN-22615173-24-3SrcApoptosisLymphocyte-specific protein tyrosine kinaseLckColo201colon cancerInhibitorinhibitorinhibit

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