2. Anti-infection
  3. SARS-CoV
  4. Lenzilumab

Lenzilumab  (Synonyms: 仑兹鲁单抗; KB 003)

目录号: HY-P99207 纯度: 99.64%
COA

摩尔计算器

Lenzilumab (KB 003) 是一种靶向 CSF2/GM-CSF 的人源单克隆抗体，可用于 COVID-19、慢性粒单核细胞白血病 (CMML) 和幼年粒单核细胞白血病 (JMML) 研究。

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CAS No. : 1229575-09-0

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规格 价格 是否有货 数量
1 mg ￥2800
In-stock
5 mg ￥7000
In-stock
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Lenzilumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lenzilumab (KB 003) is a human monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies[1][2].

同型

Human IgG1(K214R) kappa
推荐同型对照抗体
种属

Human
体内研究
(In Vivo)

Lenzilumab (i.p., 10 mg/kg, daily, 10 days) inhibits GM-CSF without inhibiting the cellular function of CAR-T and enhances its antitumor activity in NSG mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice with CART19 cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; daily; 10 days
Result: Neutralized GM-CSF, had antitumor activity and improved the proliferation of cytokine release syndrome (CRS) and neuroinflammation (NI).
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

仑兹鲁单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded GM-CSF Protein, Human (His, HY-P7016C) on AHC2 biosensor, can bind Lenzilumab with an affinity constant of 5.364E-10 M as determined in BLI assay.
纯度 & 产品资料
参考文献

Lenzilumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenzilumab1229575-09-0KB 003仑兹鲁单抗KB003KB-003SARS-CoVSARS coronavirusCSF2GM-CSFmonoclonal antibodyCOVID-19leukemiaCMMLJMMLInhibitorinhibitorinhibit

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