2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. (Leu31,Pro34)-Peptide YY (human)

(Leu31,Pro34)-Peptide YY (human) 是一种 Peptide YY (HY-P1514) 的衍生物，是一种有效的、选择性的 Y1 激动剂，KD 为 1.0 nM。

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Custom Peptide Synthesis

(Leu31,Pro34)-Peptide YY (human) Chemical Structure

(Leu31,Pro34)-Peptide YY (human) Chemical Structure

CAS No. : 179986-95-9

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(Leu31,Pro34)-Peptide YY (human) 的其他形式现货产品:

Customer Review

Other Forms of (Leu31,Pro34)-Peptide YY (human):

(Leu31,Pro34)-Peptide YY (human) 相关抗体

Top Publications Citing Use of Products

查看 Neuropeptide Y Receptor 亚型特异性产品:

查看所有亚型
NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM[1].

IC50 & Target[1]

NPY Y1 receptor

1.0 nM (Kd)

NPY Y2 receptor

670 nM (Kd)

体外研究
(In Vitro)

(Leu31,Pro34)-Peptide YY 在大鼠额顶叶皮质膜制剂 (Y1 富集组织) 和兔大隐静脉 (Y1 体外生物测定) 中表现出高亲和力 (nM)，但在 Y2 富集制剂 (大鼠海马) 中仅表现出低亲和力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Leu31,Pro34)-Peptide YY (human) 相关抗体:
体内研究
(In Vivo)

(Leu31,Pro34)-Peptide YY (0.1-1 nmol/day; ICV; 14 days) 对大鼠有抗焦虑和抗抑郁作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats weighing 150-170 g, OBX/Sham model[2]
Dosage: 0.1, 0.3 and 1 nmol/day
Administration: ICV, for 14 days
Result: Significantly decreased hyperlocomotion and immobility time in OBX animals. Reversed the deficit in social contacts in OBX animals. Reduced grooming behavior in sham animals.
分子量

4292.75

Formula

C195H296N54O56
CAS 号
Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2
Sequence Shortening

YPIKPEAPGEDASPEELNRYYASLRHYLNLLTRPRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

(Leu31,Pro34)-Peptide YY (human) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Leu31,Pro34)-Peptide YY (human)179986-95-9Neuropeptide Y ReceptorNPY receptorY1Y2Peptide YYPYYInhibitorinhibitorinhibit

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产品名称：
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目录号：
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