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  4. Leukotriene A4 methyl ester

Leukotriene A4 methyl ester  (Synonyms: LTA4 methyl ester)

目录号: HY-112621
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Leukotriene A4 methyl ester (LTA4 methyl ester) 在肥大细胞、嗜酸性粒细胞和中性粒细胞中由 5-脂氧合酶 (5-LO) 从花生四烯酸合成，该酶同时具有脂氧合酶和 LTA4 合酶活性。LTA4 被 LTA4 水解酶或 LTC4 合酶快速代谢为 LTB4 或 LTC4。已知来自白细胞的 LTA4 在血小板、红细胞和内皮细胞中进行跨细胞代谢。LTA4 被 15-LO 进一步代谢，导致脂氧素生物合成。LTA4 作为游离酸非常不稳定。甲酯稳定，可以根据需要轻松水解为游离酸。

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Leukotriene A4 methyl ester Chemical Structure

Leukotriene A4 methyl ester Chemical Structure

CAS No. : 73466-12-3

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规格 价格 是否有货 数量
25 μg ￥2640
3 - 4 周
50 μg ￥4824
3 - 4 周

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Other Forms of Leukotriene A4 methyl ester:

Leukotriene A4 methyl ester 相关抗体

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  • 生物活性

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生物活性

Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.2 LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.3 Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.2 LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

分子量

332.48

Formula

C21H32O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Leukotriene A4 methyl ester 相关分类

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Keywords:

Leukotriene A4 methyl ester73466-12-3LTA4 methyl esterOthersInhibitorinhibitorinhibit

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