Levamlodipine besylate Hemipentahydrate  (Synonyms: 苯磺酸左旋氨氯地平半五水合物)

Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine (HY-14744). Levamlodipine besylate hemipentahydrate is an orally active calcium channel blocker with antioxidant and vasodilatory properties. Levamlodipine besylate hemipentahydrate can reduce serum malondialdehyde (MDA) levels, increase superoxide dismutase (SOD) activity, and improve oxidative stress. Levamlodipine besylate hemipentahydrate can be used for research on vascular dementia, hypertension, and cerebrovascular diseases^[1][2][3][4].

1224.18

C₂₀H₂₅ClN₂O₅.C₆H₆O₃S.5/2H₂O

884648-62-8

苯磺酸左旋氨氯地平半五水合物

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yao KX, et al. Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia. Sci Rep. 2019 Dec 3;9(1):18248.  [Content Brief]

  [2]. Rong H, et al. [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 May;37(5):458-62.  [Content Brief]

  [3]. Yang YL, et al. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci Ther. 2012 Jun;18(6):471-4.  [Content Brief]

  [4]. Lee YJ, et al. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011 Dec;119(6):1262-70.  [Content Brief]