2. Apoptosis Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Apoptosis VD/VDR RAR/RXR
  4. LG190178

LG190178 是一种非甾体维生素 D 受体 (VDR) 配体，能够诱导 VDR 与视黄酸 X 受体 (RXR) 形成异二聚体复合物，并稳定 VDR 配体结合域的激动构象，从而促进 VDR 与辅激活蛋白的相互作用。LG190178 具有调节钙稳态、骨矿化以及细胞增殖、分化和凋亡 (apoptosis) 的功能，因而可用于银屑病、骨质疏松症和癌症的研究。

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LG190178 Chemical Structure

LG190178 Chemical Structure

CAS No. : 233268-81-0

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规格 是否有货
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LG190178 相关抗体

Top Publications Citing Use of Products

查看 RAR/RXR 亚型特异性产品:

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RXRα RXRβ RXRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
> 10 μM
Compound: 3a, LG190178, Diastereomeric mixture
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
[PMID: 23462715]
分子量

458.63

Formula

C28H42O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LG190178 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LG190178233268-81-0LG 190178LG-190178ApoptosisVD/VDRRAR/RXRVitamin DVitamin D receptorRetinoic acid receptorsRetinoid X receptorsVDRligandRXRbone mineralizationapoptosiscalcium homeostasisosteoporosiscancerInhibitorinhibitorinhibit

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目录号：
HY-117182
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