2. Others
  3. Isotope-Labeled Compounds
  4. Lifitegrast-d6

Lifitegrast-d6  (Synonyms: 立他司特-d6; SAR 1118-d6; SHP-606-d6)

目录号: HY-19344S1
产品使用指南

摩尔计算器

Lifitegrast-d6 (SAR 1118-d6) 是氘代标记的 Lifitegrast。Lifitegrast (SAR 1118) 是一种有效的整合素 (integrin) 拮抗剂。Lifitegrast 阻断细胞间粘附分子1 (ICAM-1) 与淋巴细胞功能相关抗原 (LFA-1) 的结合，中断 T 细胞介导的炎症周期。 Lifitegrast 抑制 Jurkat T 细胞附着于 ICAM-1 的 IC50 为 2.98 nM。Lifitegrast 可用于干眼症的研究。

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Lifitegrast-d<sub>6</sub> Chemical Structure

Lifitegrast-d6 Chemical Structure

CAS No. : 2249814-79-5

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Other Forms of Lifitegrast-d6:

Lifitegrast-d6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lifitegrast-d6 (SAR 1118-d6) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease[1][2].

分子量

621.52

Formula

C29H18D6Cl2N2O7S
CAS 号
非标记 CAS

1025967-78-5
中文名称

立他司特-d6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lifitegrast-d6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lifitegrast-d62249814-79-5SAR 1118-d6 SHP-606-d6立他司特-d6Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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