2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Ligustroside

Ligustroside  (Synonyms: Ligstroside)

目录号: HY-N3383 纯度: ≥98.0%
COA 产品使用指南 技术支持

Ligustroside (Ligstroside) 是一种 secoiridoid 衍生物，在早期阿尔茨海默病 (AD) 和脑老化模型中的线粒体生物能量学方面表现出色，其机制可能不会干扰 Aβ 的产生。Ligustroside 显着抑制脂多糖激活的 RAW264.7 巨噬细胞中一氧化氮的产生。

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Ligustroside Chemical Structure

Ligustroside Chemical Structure

CAS No. : 35897-92-8

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规格 价格 是否有货 数量
1 mg ￥2500
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Ligustroside 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SK-BR-3 IC50
> 20 μM
Compound: 9
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT reduction assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT reduction assay
[PMID: 28551177]
体外研究
(In Vitro)

Ligstroside 增加 SH-SY5Y-APP695 细胞中 SIRT1、CREB1、复合物 I 和 GPx1 的 mRNA 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ligustroside 相关抗体:
体内研究
(In Vivo)

在早期阿尔茨海默病和脑老化模型中，Ligstroside (50 mg/kg；补充饮食 6 个月) 可防止线粒体功能障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NMRI mice, aged 12 months[1]
Dosage: 50 mg/kg
Administration: Received a supplemented diet for 6 months (equivalent to 6.25 mg/kg b.w.)
Result: Showed improved spatial working memory; Restored brain ATP levels in aged mice and led to a significant life extension compared to aged control animals.
分子量

524.51

Formula

C25H32O12
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥98.0%

COA (264 KB)

产品使用指南 (1538 KB)
参考文献

Ligustroside 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ligustroside35897-92-8LigstrosideMitochondrial Metabolismsecoiridoid glucosideAlzheimer's diseasemitochondrial dysfunctionbrainageingInhibitorinhibitorinhibit

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