Linoleate sodium  (Synonyms: 顺,顺-9,12-十八碳二烯酸钠盐)

Linoleate sodium is an orally active IL8 regulator via the JNK and NF-κB pathway. Linoleate sodium can change the composition of fatty acids and the production of metabolites in cells. Linoleate sodium has anti-inflammatory, immune-regulating, and tumor cell growth-affecting activities^{[1][2][3][4][5][6][7][8][9]}.

Linoleate (0.125-1.0 mM，24 h (对于活力测试)) sodium 可提高肝细胞活力，并调节鹅原代肝细胞中的 TG 积累^[1]。
Linoleate (100-1000 μM，9 h) sodium 与 palmitate (500 μM) 结合可显著抑制 Huh7 和 HepG2 细胞中的 IL8 (mRNA 和蛋白质) 产生，低于单独的 palmitate^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Linoleate (以高亚油酸红花油形式，10% (w/w)，口服，饮食，4 周) sodium 可保存心磷脂并减轻衰竭大鼠心脏中线粒体功能障碍^[3]。
Linoleate (以含有 15% (w/w) 红花油的饮食形式；口服，通过饮食) sodium 可降低大鼠肝脏中脂肪酸合成酶活性的诱导^[4]。
Linoleate (以富含 Linoleate 的红花籽油形式，100 ppm，饮食) sodium 使抗原诱导的抗体和过敏反应小鼠血清中花生四烯酸 (20:4_{n - 6}) 水平升高^[5]。
Linoleate (以富含 Linoleate 的红花籽油形式，对应 18:2_n-6/18:3_n-3 比例为 127；喂食) sodium 在大鼠实验性胃溃疡模型中，能够减轻由乙醇、缺血/再灌注和水浸应激所诱导的胃黏膜损伤^[6]。
Linoleate sodium (1 mg/只；腹腔注射；1 次) 在接种 EAT 细胞的小鼠中，可显著提升小鼠的中位生存期，从 18 天提升到 48 天，还能完全抑制超过 40% 小鼠的肿瘤生长^[7]。
Linoleate (以富含 Linoleate 的红花籽油形式，占半纯化饮食的 10%；喂食) sodium 使 ICR 小鼠对pentobarbital 更敏感，表现为麻醉起效时间更短、麻醉持续时间更长^[8]。
Linoleate (以富含 Linoleate 的红花籽油形式，对应 18:2_n-6/18:3_n-3 比例小于 0.1；喂食) sodium 在新月型抗肾小球基底膜肾炎大鼠中，可降低尿蛋白水平、血浆尿素氮水平，减少肾小球新月体形成、纤维蛋白样坏死，同时使肾小球磷脂中花生四烯酸 (20:4_n-6) 比例更高^[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

302.43

C₁₈H₃₁NaO₂

822-17-3

固体

White to light yellow

顺,顺-9,12-十八碳二烯酸钠盐

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Pan Z, et al. Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. Comp Biochem Physiol A Mol Integr Physiol. 2011 Jun;159(2):113-8.  [Content Brief]

  [2]. Maruyama H, et al. Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. Lipids Health Dis. 2014 May 13;13:78.  [Content Brief]

  [3]. Mulligan CM, et al. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. Cardiovasc Res. 2012 Jun 1;94(3):460-8.  [Content Brief]

  [4]. Flick PK, et al. Effect of dietary linoleate on synthesis and degradation of fatty acid synthetase from rat liver. J Biol Chem. 1977 Jun 25;252(12):4242-9.  [Content Brief]

  [5]. Oh-hashi K, et al. Reevaluation of the effect of a high alpha-linolenate and a high linoleate diet on antigen-induced antibody and anaphylactic responses in mice. Biol Pharm Bull. 1997 Mar;20(3):217-23.  [Content Brief]

  [6]. Matsuba S, et al. Effect of dietary linoleate/alpha-linolenate balance on experimentally induced gastric injury in rats. Prostaglandins Leukot Essent Fatty Acids. 1998 Nov;59(5):317-23.  [Content Brief]

  [7]. Norman A, et al. Antitumor activity of sodium linoleate. Nutr Cancer. 1988;11(2):107-15.  [Content Brief]

  [8]. Nakashima Y, et al. Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. J Lipid Res. 1993 Feb;34(2):239-47.  [Content Brief]

  [9]. Watanabe S, et al. Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats. Lipids. 1990 May;25(5):267-72.  [Content Brief]