Liothyronine  (Synonyms: 三碘甲状腺原氨酸; Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively^[1].

TRβ1^[1][2]

Liothyronine (GMP) 可用于诱导人角质形成细胞生成诱导性多能干细胞^[1]。
Liothyronine (GMP) 是角膜缘干细胞 (LSC) 增殖和自我更新所必需的^[2]。
Liothyronine (GMP) (4 nM) 促进胚胎干细胞的心脏分化和成熟^[3]。
Liothyronine (GMP) (100 nM，14 天) 促进人诱导多能干细胞 (hiPSC) 来源的心肌细胞的电生理成熟^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

650.97

C₁₅H₁₂I₃NO₄

6893-02-3

固体

White to off-white

三碘甲状腺原氨酸 (GMP)； 碘噻罗宁 (GMP)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aasen T, et al. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Protoc. 2010 Feb;5(2):371-82.  [Content Brief]

  [2]. Yu M, et al. An important role for adenine, cholera toxin, hydrocortisone and triiodothyronine in the proliferation, self-renewal and differentiation of limbal stem cells in vitro. Exp Eye Res. 2016 Nov;152:113-122.  [Content Brief]

  [3]. CY, et al. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36.  [Content Brief]

  [4]. Wang L, et al. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Dec;161:130-138.  [Content Brief]