2. 诱导疾病模型产品 Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. 免疫与炎症疾病模型 Thyroid Hormone Receptor Endogenous Metabolite
  4. 半抗原
  5. Liothyronine

Liothyronine  (Synonyms: 三碘甲状腺原氨酸; Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

目录号: HY-A0070A 纯度: 99.82%
COA 产品使用指南

摩尔计算器

Liothyronine 是一种有效的甲状腺激素。Liothyronine 结合 TRα 和 TRβ 激动剂，对 hTRα 和 hTRβ 的 Ki 值分别为 2.33 和 2.29 nM。Liothyronine 也能与 PVR 结合，阻断 TIGIT/PVR 的相互作用。

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Liothyronine Chemical Structure

Liothyronine Chemical Structure

CAS No. : 6893-02-3

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规格 价格 是否有货 数量
100 mg ￥450
In-stock
500 mg ￥1200
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Customer Review

Other Forms of Liothyronine:

Liothyronine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with Kis of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
3.4 nM
Compound: T3
Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay
Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay
[PMID: 32356658]
CHO EC50
6.2 nM
Compound: T3
Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay
Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay
[PMID: 32356658]
CV-1 EC50
0.002 μM
Compound: T3
Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
[PMID: 24290064]
CV-1 EC50
0.0021 μM
Compound: T3
Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
[PMID: 24290064]
CV-1 EC50
0.5 nM
Compound: T3
Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay
Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay
[PMID: 32356658]
CV-1 EC50
1.2 nM
Compound: T3
Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay
Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay
[PMID: 32356658]
HEK293 EC50
0.41 nM
Compound: T3
Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 25305688]
HEK-293T EC50
5.8 μM
Compound: T3
Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay
Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay
[PMID: 32356658]
HeLa EC50
2.4 nM
Compound: T3
Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay
Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay
[PMID: 17988877]
HeLa EC50
2.4 nM
Compound: T3
Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay
Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay
[PMID: 17988877]
LNCaP IC50
> 50 μM
Compound: 6, T3
Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis
Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis
[PMID: 22047606]
Sf9 EC50
0.5 nM
Compound: T3
Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis
Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis
[PMID: 32356658]
U2OS EC50
11 nM
Compound: T3
Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay
Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay
[PMID: 17988877]
U2OS EC50
2.4 nM
Compound: T3
Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay
Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay
[PMID: 17988877]
体外研究
(In Vitro)

Liothyronine (T3，100 nM) 刺激 TRβ1 过表达的肝癌细胞的增殖[1]。
Liothyronine 与人类 β1 甲状腺激素受体 (hTRβ1) 结合，并改变其构象。Liothyronine 促进生长、诱导分化和调节代谢作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Liothyronine 相关抗体:
Clinical Trial
分子量

650.97

Formula

C15H12I3NO4
CAS 号
性状

固体

颜色

White to off-white

中文名称

三碘甲状腺原氨酸； 碘噻罗宁
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (76.81 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

1M NaOH 中的溶解度 : 50 mg/mL (76.81 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5362 mL 7.6808 mL 15.3617 mL
5 mM 0.3072 mL 1.5362 mL 3.0723 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.82%

COA (283 KB) HNMR (252 KB) LCMS (257 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of Liothyronine (T3) on the growth of cells, cells are plated at a density of 3 × l04 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Liothyronine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 1.5362 mL 7.6808 mL 15.3617 mL 38.4042 mL
5 mM 0.3072 mL 1.5362 mL 3.0723 mL 7.6808 mL
10 mM 0.1536 mL 0.7681 mL 1.5362 mL 3.8404 mL
15 mM 0.1024 mL 0.5121 mL 1.0241 mL 2.5603 mL
20 mM 0.0768 mL 0.3840 mL 0.7681 mL 1.9202 mL
25 mM 0.0614 mL 0.3072 mL 0.6145 mL 1.5362 mL
30 mM 0.0512 mL 0.2560 mL 0.5121 mL 1.2801 mL
40 mM 0.0384 mL 0.1920 mL 0.3840 mL 0.9601 mL
50 mM 0.0307 mL 0.1536 mL 0.3072 mL 0.7681 mL
60 mM 0.0256 mL 0.1280 mL 0.2560 mL 0.6401 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Liothyronine6893-02-3Triiodothyronine 3,3',5-Triiodo-L-thyronine T3三碘甲状腺原氨酸 碘噻罗宁T3T 3T-3Thyroid Hormone ReceptorEndogenous MetaboliteTHRthyroid hormoneTRαTRβInhibitorinhibitorinhibit

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