2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Interleukin Related Endogenous Metabolite
  4. Lipoxin A4

Lipoxin A4  (Synonyms: 脂氧素 A4; LXA4)

目录号: HY-113509 纯度: 99.19%
COA 产品使用指南

摩尔计算器

Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类二十烷酸调节剂，具有强大的抗炎和促消炎双重特性。Lipoxin A4 抑制与 ERK1/2 和 NF-kB 通路相关的人表皮角质形成细胞 (NHEK) 的增殖以及炎性细胞因子/趋化因子(如IL-6，IL-8等)的产生。Lipoxin A4 抑制血清淀粉样蛋白 A (SAA) 介导的 IL-8 释放，IC50 值为 25.74 nM。

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Lipoxin A4 Chemical Structure

Lipoxin A4 Chemical Structure

CAS No. : 89663-86-5

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规格 价格 是否有货 数量
25 μg（283.71 µM * 250 μL in Ethanol） ￥6000
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Other Forms of Lipoxin A4:

Lipoxin A4 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].

IC50 & Target

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
THP-1 IC50
1 pM
Compound: 1
Anti-inflammatory activity against human THP-1 monocytes assessed as reduction in LPS-induced IL-6 release pretreated for 30 mins followed LPS stimulation and measured after 24 hrs by multiplex chemiluminescence detection method
Anti-inflammatory activity against human THP-1 monocytes assessed as reduction in LPS-induced IL-6 release pretreated for 30 mins followed LPS stimulation and measured after 24 hrs by multiplex chemiluminescence detection method
[PMID: 34138563]
THP-1 IC50
1 pM
Compound: 1
Anti-inflammatory activity against human THP-1 monocytes assessed as reduction in LPS-induced IL-1beta release pretreated for 30 mins followed LPS stimulation and measured after 24 hrs by multiplex chemiluminescence detection method
Anti-inflammatory activity against human THP-1 monocytes assessed as reduction in LPS-induced IL-1beta release pretreated for 30 mins followed LPS stimulation and measured after 24 hrs by multiplex chemiluminescence detection method
[PMID: 34138563]
THP-1 IC50
1 pM
Compound: 1
Anti-inflammatory activity against human THP-1 monocytes assessed as reduction in LPS-induced IFNgamma release pretreated for 30 mins followed LPS stimulation and measured after 24 hrs by multiplex chemiluminescence detection method
Anti-inflammatory activity against human THP-1 monocytes assessed as reduction in LPS-induced IFNgamma release pretreated for 30 mins followed LPS stimulation and measured after 24 hrs by multiplex chemiluminescence detection method
[PMID: 34138563]
THP-1 EC50
5 nM
Compound: 1
Induction of phagocytosis in human THP-1-MF0 macrophages pretreated for 30 mins followed by fluorescently labeled Escherichia coli derived bio-particles addition and measured after 2 hrs
Induction of phagocytosis in human THP-1-MF0 macrophages pretreated for 30 mins followed by fluorescently labeled Escherichia coli derived bio-particles addition and measured after 2 hrs
[PMID: 34138563]
体外研究
(In Vitro)

Lipoxin A4 (LXA4) inhibits the expression of IL-6 and IL-8 in NHEKs[2].
Lipoxin A4 downregulates the expression of cyclin D1[2].
Lipoxin A4 also suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation of NHEKs[2].
LXA4 (100 nM; preincubation for 30 minutes)inhibits the proliferation of NHEKs with or without stimulating by LPS (10 μg/mL)[2].
LXA4 pretreatment (100  nM for 30 minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lipoxin A4 相关抗体:

Cell Proliferation Assay[2]

Cell Line: Normal human epidermal keratinocytes (NHEKs)
Concentration: 100 nM
Incubation Time: 30 minutes
Result: A significant increase in proliferation of NHEKs after 7 days of stimulation with LPS (10 μg/mL) was seen. However, there was a significant decrease in the proliferation of NHEKs when pretreated with LXA4 for 30 min.

Western Blot Analysis[1]

Cell Line: Normal human epidermal keratinocytes (NHEKs)
Concentration: 100 nM
Incubation Time: 30 minutes.
Result: HMGB1 protein levels in the cytoplasm of NHEKs were induced by LPS, which were decreased after preincubation with LXA4 but decreased in the nucleus after stimulation with LPS.
分子量

352.47

Formula

C20H32O5
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

脂氧素 A4
结构分类
初始来源
运输条件

Shipping with dry ice.
储存方式

Solution, -20°C, 1 year
纯度 & 产品资料

纯度: 99.19%

COA (277 KB)

产品使用指南 (1538 KB)
参考文献

Lipoxin A4 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipoxin A489663-86-5LXA4脂氧素 A4Lipoxin A 4Lipoxin A-4LXA 4LXA-4Interleukin RelatedEndogenous MetaboliteILlipoxin A4,IL-6interleukin-6,IL-8interleukin-8,NHEKsepidermal keratinocytesLPSlipopolysaccharideERK1/2,NF-kBInhibitorinhibitorinhibit

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目录号：
HY-113509
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