2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. LM11A-31

LM11A-31 是一种 p75NTR (神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。LM11A-31 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。LM11A-31 可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。

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LM11A-31 Chemical Structure

LM11A-31 Chemical Structure

CAS No. : 102562-74-3

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LM11A-31 的其他形式现货产品:

Other Forms of LM11A-31:

LM11A-31 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LM11A-31, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression[1][2].

体内研究
(In Vivo)

LM11A-31 (口服灌胃；50 mg/kg/天，持续4周) 显著减轻了前神经生长因子proNGF的积累，并保持了血脑屏障的完整性[1]。
LM11A-31 (口服；50或75 mg/kg) 在6-8个月龄开始，持续3个月的给药，能防止和/或逆转中期雄性APPL/S小鼠基底前脑胆碱能神经突起和皮层退化性神经突起的萎缩[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 J mice[1].
Dosage: 50 mg kg/day
Administration: Oral gavage; for 4 weeks
Result: Mitigated proNGF accumulation and preserved BRB integrity.
分子量

243.35

Formula

C12H25N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LM11A-31 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM11A-31102562-74-3Neurokinin ReceptorNK receptorTachykinin receptorp75neurotrophin receptorHIVAlzheimer's diseaseInhibitorinhibitorinhibit

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