2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR Dopamine Transporter
  4. Lobeline sulfate

Lobeline sulfate  (Synonyms: 硫酸山梗菜碱; α-Lobeline sulfate; L-Lobeline sulfate)

目录号: HY-128420
产品使用指南

摩尔计算器

Lobeline (α-Lobeline) sulfate 是一种可穿过血脑屏障的烟碱受体 (nicotinic receptor) 激动剂。Lobeline sulfate 通过抑制突触小泡摄取 DA 并改变突触前 DA 储存来增加多巴胺 (DA) 的释放。Lobeline sulfate 对戒烟有效。

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Lobeline sulfate Chemical Structure

Lobeline sulfate Chemical Structure

CAS No. : 134-64-5

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Other Forms of Lobeline sulfate:

Lobeline sulfate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation[1][2].

IC50 & Target

IC50: endogenous metabolite[1]
体外研究
(In Vitro)

Lobeline (0.1-100 μM) sulfate 诱导 [3H]DA 溢出呈非钙依赖性[1]。
Lobeline sulfate 抑制 [3H]DA 被突触小体 (IC50=80 μM) 和囊泡 (IC50=0.88 μM) 摄取[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lobeline sulfate 相关抗体:
体内研究
(In Vivo)

Lobeline sulfate (0.3-3.0 mg/kg; 皮下注射; 单剂量) 降低模型大鼠 d-methamphetamine 的自我给药能力[3]。
Lobeline sulfate (3 mg/kg; 皮下注射; 7 个周期，共 7 次) 以非竞争性的方式特别降低大鼠对 d-Methamphetamine 的反应，并增加耐受性发展[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (200-250 g)[3]
Dosage: 0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration
Administration: Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration
Result: Decreased d-methamphetamine Self-Administration.
Clinical Trial
分子量

772.99

Formula

C44H56N2O8S
CAS 号
中文名称

硫酸山梗菜碱； 硫酸洛贝林
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lobeline sulfate 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lobeline134-64-5α-LobelineL-Lobeline硫酸山梗菜碱 硫酸洛贝林nAChRDopamine TransporterNicotinic acetylcholine receptorsDATSLC6A3attention deficit hyperactivity disorderADHD dopamine uptakehyperactivity smoking cessationInhibitorinhibitorinhibit

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