2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. LOE 908 hydrochloride

LOE 908 hydrochloride 是非选择性阳离子通道 (NSCC) 抑制剂。

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LOE 908 hydrochloride Chemical Structure

LOE 908 hydrochloride Chemical Structure

CAS No. : 143482-60-4

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LOE 908 hydrochloride 的其他形式现货产品:

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Other Forms of LOE 908 hydrochloride:

LOE 908 hydrochloride 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
12.6 μM
Compound: LOE 908 Hydrochloride
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
3.2 μM
Compound: LOE 908 Hydrochloride
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
体外研究
(In Vitro)

LOE 908 hydrochloride 以浓度依赖方式阻断阳离子电导，IC50 为 560 nM。在电压钳位的 A7r5 细胞中，通过电压依赖的 Ca2+ 通道阻断二氢吡化物敏感的 Ba2+ 电流， IC50 为 28 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LOE 908 hydrochloride 相关抗体:
体内研究
(In Vivo)

LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride 可减轻大鼠急性神经运动功能障碍[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats, lateral fluid percussion brain injury model[2]
Dosage: 4 mg/kg bolus followed by 160 mg/kg over 24 h or 2 mg/kg bolus followed by 80 mg/kg over 24 h
Administration: Intravenous administration
Result: Significantly improved neuromotor function at 48 h postinjury when compared to vehicle treatment.
分子量

749.29

Formula

C41H49ClN2O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LOE 908 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LOE 908143482-60-4LOE908LOE-908Calcium ChannelCa2+ channelsCa channelsNSCCcation channelneuromotor dysfunctionInhibitorinhibitorinhibit

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产品名称：
LOE 908 hydrochloride
目录号：
HY-107756
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