2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. LT-630

LT-630 是一种 HDAC6 抑制剂。LT-630 通过减小氧化应激损伤来缓解肝损伤。

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LT-630 Chemical Structure

LT-630 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

LT-630 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LT-630 is a HDAC6 inhibitor. LT-630 ameliorates liver injury by reducing oxidative damage[1].

IC50 & Target[1]

HDAC6

 

体外研究
(In Vitro)

LT-630 (2-8 nM，3 小时和 24 小时) 可抑制对乙酰氨基酚 (Acetaminophen (HY-66005)) 诱导的细胞损伤，减少 AML-12 细胞中增加的氧化应激和细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LT-630 相关抗体:

Western Blot Analysis[1]

Cell Line: AML-12 cells
Concentration: 2-8 nM
Incubation Time: 3 h and 24 h
Result: Reduced the increased ratio of bax/bcl-2 and the levels of cleaved caspase3 and cyt-c.
体内研究
(In Vivo)

LT-630 (10-40 mg/kg，静脉注射，APAP 给药前) 通过消除 ROS 来抑制对乙酰氨基酚 (APAP) 诱导的小鼠氧化应激和肝细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male C57BL/6J mice (16–20 g, 6-week-old)[1]
Dosage: 10-40 mg/kg befor APAP (350 mg/kg, i.p.)
Administration: tail vein injection
Result: Enhanced the release of GSH, SOD and NADPH.
Reduced apoptosis, the bax/bcl-2 ratio, and the levels of cleaved caspase3 and cyt-c in APAP.
分子量

368.36

Formula

C19H17FN4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LT-630 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LT-630LT630LT 630HDACHistone deacetylasesliver injuryROSoxidative stressInhibitorinhibitorinhibit

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产品名称：
LT-630
目录号：
HY-162378
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