2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. LIM Kinase (LIMK) ROCK PKA
  4. LX7101 monohydrochloride

LX7101 monohydrochloride 是一种有效的 LIM 激酶、ROCK 和 PKA 抑制剂，对 LIMK1、LIMK2、ROCK2 和 PKA 的 IC50 分别为 24 nM、1.6 nM、10 nM 和 <1 nM。LX7101 monohydrochloride 在 2 μM ATP 下对 LIMK2 具有显著的选择性，对 LIMK2 和 LIMK1 的 IC50 值分别为 4.3 nM 和 32 nM。LX7101 monohydrochloride 具有用于眼高压和相关青光眼研究的潜力。

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LX7101 monohydrochloride Chemical Structure

LX7101 monohydrochloride Chemical Structure

CAS No. : 2319882-48-7

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LX7101 monohydrochloride 的其他形式现货产品:

Other Forms of LX7101 monohydrochloride:

LX7101 monohydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

WB
Proliferation Assay

    LX7101 monohydrochloride purchased from MCE. Usage Cited in: Oncogene. 2023 Mar 16.  [Abstract]

    Both LX7101 (5 μM) and TH-257 (5 μM) inhibits the colony-forming ability of melanoma cells (A375-MA2, MeWo, and SK-MEL-147 cells) in soft-agar.

    LX7101 monohydrochloride purchased from MCE. Usage Cited in: Oncogene. 2023 Mar 16.  [Abstract]

    Both LX7101 (5 μM; 24 h) and TH-257 (5 μM; 24 h) reduces the phosphorylation of G3BP1 in A375-MA2 and SK-MEL-147 cells.

    LX7101 monohydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Aug 2;8(1):11585.  [Abstract]

    Western blot analysis of GFAP protein levels in LX7101 and DMSO-treated iNPC-KO lines. GAPDH is used as a loading control.

    查看 LIM Kinase (LIMK) 亚型特异性产品:

    查看所有亚型
    LIMK1 LIMK2

    查看 ROCK 亚型特异性产品:

    查看所有亚型
    ROCK ROCK1 ROCK2

    查看 PKA 亚型特异性产品:

    查看所有亚型
    PKA PKAR

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research[1][2].

    IC50 & Target[1]

    LIMK1

    24 nM (IC50)

    LIMK2

    1.6 nM (IC50)

    ROCK2

    10 nM (IC50)

    PKA

    <1 nM (IC50)

    体内研究
    (In Vivo)

    LX7101 (200 μg/40 μL 滴眼液) monohydrochloride 在眼压正常的新西兰白兔 (NZW) 中给药后 1 小时至 6 小时的时间点，眼压 (IOP) 显著降低[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    487.98

    Formula

    C23H30ClN7O3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    LX7101 monohydrochloride 相关分类

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    Keywords:

    LX7101 monohydrochloride2319882-48-7LIM Kinase (LIMK)ROCKPKALIMKsRho-associated protein kinaseRho-associated kinaseRho-kinaseROKProtein kinase Aocular hypertensionglaucomaInhibitorinhibitorinhibit

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