2. Neuronal Signaling
  3. Beta-secretase
  4. LY3202626

LY3202626 是 CNS 穿透性 BACE 抑制剂，对 BACE1 和 BACE2 的?IC50 分别为 0.615 nM 和 0.871 nM。

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LY3202626 Chemical Structure

LY3202626 Chemical Structure

CAS No. : 1628690-73-2

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LY3202626 相关抗体

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查看 Beta-secretase 亚型特异性产品:

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BACE1 BACE2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY3202626 is a CNS penetrant BACE inhibitor with IC50s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively[1].

IC50 & Target

IC50: 0.615 nM (BACE1), 0.871 nM (BACE2)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.615 nM
Compound: 7; LY-3202626
Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay
Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay
[PMID: 30709653]
分子量

498.51

Formula

C22H20F2N8O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY3202626 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY32026261628690-73-2LY 3202626LY-3202626Beta-secretaseBACEβ-SecretaseCNS penetrantliver injuryInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-118098
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