2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Lys-[Des-Arg9]Bradykinin

Lys-[Des-Arg9]Bradykinin 是一种天然存在的激肽，是一种有效且高度选择性的缓激肽 B1 受体激动剂，对人，小鼠和兔子的 B1 受体的 Ki 值为 0.12 nM，1.7 nM 和 0.23 nM。Lys-[Des-Arg9]Bradykinin 对 B2 受体的抑制活性较低。

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Custom Peptide Synthesis

Lys-[Des-Arg9]Bradykinin Chemical Structure

Lys-[Des-Arg9]Bradykinin Chemical Structure

CAS No. : 71800-36-7

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规格 价格 是否有货 数量
1 mg ￥3067
3 - 4 周
5 mg   询价  
10 mg   询价  

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Other Forms of Lys-[Des-Arg9]Bradykinin:

Lys-[Des-Arg9]Bradykinin 相关抗体

Top Publications Citing Use of Products

查看 Bradykinin Receptor 亚型特异性产品:

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
IMR-90 IC50
0.87 nM
Compound: (Des-Arg10)-Kallidin
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
[PMID: 23403082]
体外研究
(In Vitro)

Lys-[Des-Arg9]Bradykinin 由缓激肽的蛋白水解裂解形成，通过缓激肽 B1 受体 (B1R) 发挥作用[1]。
Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) 增强 IL-12p70 的分泌并抑制成熟 hMo-DC 的 IL-12p40 分泌。用 Lys-[Des-Arg9]Bradykinin 预处理可减少成熟 hMo-DC 单独向培养基的迁移，表明 Lys-[Des-Arg9]Bradykinin 可抑制成熟 hMo-DC 的趋化作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lys-[Des-Arg9]Bradykinin 相关抗体:
体内研究
(In Vivo)

Lys-[Des-Arg9]Bradykinin (1 μg；鼻腔注射；新西兰大白兔) 处理可降低脂多糖诱导家兔外周血管阻力，但效果短暂(T1/2=118-195 s)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1032.20

Formula

C50H73N13O11
CAS 号
Sequence

Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe
Sequence Shortening

KRPPGFSPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Lys-[Des-Arg9]Bradykinin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lys-[Des-Arg9]Bradykinin71800-36-7Bradykinin ReceptorBradykininIL-12p70IL-12p40hypotensiveInhibitorinhibitorinhibit

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目录号：
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