2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. MAGL Calcium Channel
  4. MAGL-IN-13

MAGL-IN-13（compound(3R,4S)-5v）是一种有选择性的，不可逆的 MAGL 抑制剂，mMAGL，hMAGL 和 rMAGL 的IC50 值分别是 0.026，0.021 和 0.24 nM。MAGL-IN-13 具有血脑屏障穿透性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MAGL-IN-13 Chemical Structure

MAGL-IN-13 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MAGL-IN-13 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAGL-IN-13 (compound (3R, 4S) - 5v) is a selective, irreversible inhibitor for MAGL,with IC50 values of 0.026, 0.021 and 0.24 nM for mMAGL, hMAGL and rMAGL, respectively. MAGL-IN-13 can penetrant blood brain barrier. [1].

IC50 & Target

rats Ca2+ channel (10 μM)[1]
体外研究
(In Vitro)

MAGL-IN-13 （37 ℃预孵育 10 分钟）可以抑制mMAGL，hMACL 和 rMACL，IC50 值分别是0.026，0.021 和0.24 nM[1]。
MAGL-IN-13 不可逆的抑制 MAGL 活性[1]。
MAGL-IN-13（0.1 和 1 μM）对 MAGL 具有选择性[1]。
MAGL-IN-13 在小鼠成纤维细胞 NIH3T3 中显示低细胞毒性，细胞活力的IC50值是 0.47 μM[1]。
MAGL-IN-13 在10 μM 浓度下可以抑制大鼠的 Ca2+ 通道[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAGL-IN-13 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: NIH 3T3
Concentration: 4, 13, 22, 34, 47, 60 μM
Incubation Time: 24 h
Result: Exhibited low cytotoxic potential.

Cell Viability Assay[1]

Cell Line: NIH 3T3
Concentration: 4, 13, 22, 34, 47, 60 μM
Incubation Time: 24 h
Result: Revealed an IC50 of 47 μM.
体内研究
(In Vivo)

MAGL-IN-13（腹腔注射，5 mg/kg）抑制大脑 MAGL 的活性，具有剂量依赖性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MAGL inhibition/adult male mice [1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited brain MAGL activity.
分子量

513.52

Formula

C28H24FN5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAGL-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAGL-IN-13MAGLCalcium ChannelMonoacylglycerol lipaseCa2+ channelsCa channelsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MAGL-IN-13
目录号：
HY-163202
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z