2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. MAGL-IN-3

MAGL-IN-3 是单酰甘油脂肪酶 (MAGL；IC50=34.1 nM) 的抑制剂。当浓度为 1 μM 时，它可以减少 Neuro2a 细胞中过氧化氢诱导的乳酸脱氢酶 (LDH) 释放。MAGL-IN-3 (10 mg/kg) 可增加小鼠脑中 2-花生四烯酸甘油的含量。

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MAGL-IN-3 Chemical Structure

MAGL-IN-3 Chemical Structure

CAS No. : 2514-37-6

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MAGL-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50=34.1 nM). It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
3.58 μM
Compound: 13; BTZ 13
Inhibition of mouse ABHD6 expressed in HEK293 cells using 2-AG as substrate
Inhibition of mouse ABHD6 expressed in HEK293 cells using 2-AG as substrate
[PMID: 31714779]
HeLa IC50
242.9 nM
Compound: 13; BTZ 13
Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
[PMID: 31714779]
HeLa IC50
34.1 nM
Compound: 13; BTZ 13
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
[PMID: 31714779]
HeLa IC50
604.7 nM
Compound: 13; BTZ 13
Inhibition of recombinant rat MGL C201A/C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
Inhibition of recombinant rat MGL C201A/C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
[PMID: 31714779]
HeLa IC50
72.6 nM
Compound: 13; BTZ 13
Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by LC-MS analysis
[PMID: 31714779]
分子量

255.33

Formula

C15H13NOS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAGL-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAGL-IN-32514-37-6Endogenous MetaboliteInhibitorinhibitorinhibit

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