2. Metabolic Enzyme/Protease Anti-infection Immunology/Inflammation NF-κB
  3. Endogenous Metabolite Glycosidase Bacterial Interleukin Related Reactive Oxygen Species
  4. Mannan

Mannan  (Synonyms: 甘露聚糖)

目录号: HY-W145667 含量: 98.10%
COA 产品使用指南 技术支持

Mannan 是一种口服活性的与甘露糖受体 (MR) 结合的多糖化合物。Mannan 通过与 MR 结合，促进细菌 (bacterial) 的摄取和内部降解，进而增强免疫细胞中 IL-12 的产生。Mannan 增强 ROS 产生。Mannan 调节免疫、抑制 Aflatoxin B1 (HY-N6615) 诱导的毒性、降低血脂。

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Mannan Chemical Structure

Mannan Chemical Structure

CAS No. : 9036-88-8

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Mannan 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615)-induced toxicity, and reduces lipid[1][2][3][4].

体外研究
(In Vitro)

Mannan (10-100 μg/mL，30 分钟) 通过增加嗜酸乳杆菌和金黄色葡萄球菌刺激的树突状细胞中的细菌摄取和内体降解来增强 IL-12 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mannan 相关抗体:

Western Blot Analysis[1]

Cell Line: Murine bone marrow-derived dendritic cells (BMDCs)
Concentration: 10 µg/mL, 100 µg/mL
Incubation Time: 30 min for pretreatment before bacteria stimulation; 60 min before adding bacteria for endocytosis assay; 1 h for MR surface expression assay
Result: Led to a decrease in the surface expression of the mannose receptor (MR) detected.

Real Time qPCR[1]

Cell Line: Murine bone marrow-derived dendritic cells (BMDCs)
Concentration: 10 µg/mL, 100 µg/mL
Incubation Time: 30 min for pretreatment before bacteria stimulation; 60 min before adding bacteria for endocytosis assay; 1 h for MR surface expression assay
Result: Increased the expression of IFN-β in cells stimulated with L. acidophilus.
体内研究
(In Vivo)

Mannan (50-500 ppm；口服，饮食给予；每天；治疗 4 周) 降低小鼠中 Aflatoxin B1 (HY-N6615) 诱导的毒性，表现为体重增加、微核正常染色红细胞率降低和姐妹染色单体交换率降低[2]。
Mannan (50-100 mg/kg；腹腔注射；2-5 次) 降低 poloxamer 407 (HY-D1005) 诱导的急性血脂异常小鼠的低密度脂蛋白 (LDL)、胆固醇和甘油三酯的血清含量[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CBA/Lac mice (2.5-3-month-old, weighing 22-25 g), acute lipemia induced by poloxamer 407 model[4]
Dosage: 50 mg/kg, 100 mg/kg
Administration: Intraperitoneal injection, 5 times at 50 mg/kg every other day or 2 times at 100 mg/kg with 1-day interval
Result: Reduced the levels of triglyceride, atherogenic LDL, and total cholesterol in the serum at 50 mg/kg and 100 mg/kg.
Decreased the triglyceride concentration in the liver.
Increased the lability of lysosomal membranes in the liver and elevated the serum activity of chitotriosidase, a marker of macrophage activation.
Clinical Trial
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

甘露聚糖
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (超声助溶)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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动物溶解方案计算器
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工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.10%

COA (258 KB)

产品使用指南 (1538 KB)
参考文献

Mannan 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mannan9036-88-8甘露聚糖Endogenous MetaboliteGlycosidaseBacterialInterleukin RelatedReactive Oxygen SpeciesILbiochemical assayreagentInhibitorinhibitorinhibit

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