2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-28

MAO-B-IN-28 (compound 10e) 是一种有效的 hMAO-B 抑制剂，IC50 为 1.9±0.5 nM。MAO-B-IN-28 或可成为神经退行性疾病研究的一个候选分子。

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MAO-B-IN-28 Chemical Structure

MAO-B-IN-28 Chemical Structure

CAS No. : 3028096-72-9

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MAO-B-IN-28 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research[1].

IC50 & Target

monoamine oxidase B (MAO-B) IC50: 1.9±0.5 nM[1]
体外研究
(In Vitro)

MAO-B-IN-28 (0.5-128 μM, 24 h) 对 MCF-7 细胞有明显的细胞毒作用，而对 MGC-803、HCT-116 和 HepG2 无明显的细胞毒作用。MAO-B-IN-28 (0.5, 4 μM, 24 h) 对分化 SH-SY5Y 细胞和 HVSMC 细胞均无细胞毒性[1]。
MAO-B-IN-28 (2, 4 μM, 24 h) 不会引起分化的 SH-SY5Y 细胞内 ROS 水平的增加或造成氧化损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-28 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7, MGC-803, HCT-116 and HepG2
Concentration: 0.5, 1, 2, 4, 8, 16, 32, 64, 128 μM
Incubation Time: 24 h
Result: Exhibited cytotoxicity IC50s (μM) of 5.816, 21.38, 83.16, 39.64 for MCF-7, HCT-116, HepG2 and MGC-803 cells, respectively.
分子量

405.35

Formula

C19H10F3NO4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-283028096-72-9Monoamine OxidaseMAOHVSMCMCF-7HCT-116HepG2MGC-80SH-SY5YHuman monoamine oxidase BinhibitorThiochromoneneurodegenerative diseaseInhibitorinhibit

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产品名称：
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目录号：
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