2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-4

MAO-B-IN-4 (Compound 26) 是一种具有口服活性的，可逆的 MAO-B 抑制剂，其 IC50 为 9 nM。MAO-B-IN-4 具有良好的代谢稳定性，安全性并且可透过血脑屏障。MAO-B-IN-4 在大鼠和小鼠中显示抗抑郁的活性。MAO-B-IN-4 在星形胶质细胞有神经胶质保护作用。MAO-B-IN-4 可用于阿尔茨海默病相关研究。

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MAO-B-IN-4 Chemical Structure

MAO-B-IN-4 Chemical Structure

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MAO-B-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC50 of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease[1].

体外研究
(In Vitro)

MAO-B-IN-4 (0.25 μM 24 小时暴露于 0.5μM DOX 中) 在培养的星形胶质细胞模型中显示了明显的神经胶质保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-4 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 0.1-100 µM
Incubation Time: 72 h
Result: Showed no effect on the viability of the cells after 24 hours of exposure.
体内研究
(In Vivo)

MAO-B-IN-4 (1 和 3 mg/kg, 口服, 2 h) 可以防止东莨菪碱引起的短期记忆障碍[1]。
MAO-B-IN-4 (0.312-2.5 mg/kg, 静脉注射, 1 h) 在强迫游泳试验中表现出小鼠抗抑郁的特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats treated with anticholinergic scopolamine[1]
Dosage: 1 and 3 mg/kg
Administration: Oral administration; 2h before the experiment
Result: Orally 2 h before the acquisition trial prevented scopolamine-induced short-term memory deficits
Animal Model: Mice models[1]p>
Dosage: 0.312-2.5 mg/kg
Administration: Intraperitoneal injection; 1h
Result: Resulted a similar effect with antidepressant S-citalopram (HY-14258) under the dose of 0.625 mg/kg and 1.25 mg/kg, respecively.
分子量

411.87

Formula

C23H20ClF2N3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-4Monoamine OxidaseMAOAlzheimer's diseaseGliaCognitionFluorinated compoundsInhibitorinhibitorinhibit

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目录号：
HY-143330
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