2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-5

MAO-B-IN-5 是一种有效的、选择性和具有口服活性的 MAO-B 抑制剂，IC50 值为 0.204 µM。MAO-B-IN-5 具有研究帕金森病 (PD) 的潜力。

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MAO-B-IN-5 Chemical Structure

MAO-B-IN-5 Chemical Structure

CAS No. : 849909-77-9

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MAO-B-IN-5 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1].

IC50 & Target

MAO-B

34.190 μM (IC50)

MAO-A

0.204 μM (IC50)

体外研究
(In Vitro)

MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 µM and 0.204 µM for MAO-A and MAO-B, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-5 相关抗体:
体内研究
(In Vivo)

MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)[1].
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].

Compound Route Dose (mg/kg) Cmax (ng/mL) AUCt (ng·h/mL) T1/2 (h) Vss (h) Cl (mL/min/kg) F (%)
D0 iv 1 809 347 0.37 1.11 47.1 /
po 5 163 284 1.27 / / 16.3
SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o.[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1]
Dosage: 1, 5 mg/kg
Administration: 1 mg/kg, i.v.; 5 mg/kg, p.o.
Result: Showed oral bioavailability in rats (F=16.3%).
分子量

328.38

Formula

C19H21FN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-5849909-77-9Monoamine OxidaseMAOSafinamideParkinson's disease (PD)dopamineselectiveorally activeSD ratsSf9 cellsInhibitorinhibitorinhibit

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目录号：
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