2. Academic Validation
  3. Synthesis and structure-activity relationships of new second-generation taxoids

Synthesis and structure-activity relationships of new second-generation taxoids

  • Bioorg Med Chem Lett. 1999 Dec 20;9(24):3423-8. doi: 10.1016/s0960-894x(99)00629-0.
I Ojima 1,  T Wang,  M L Miller,  S Lin,  C P Borella,  X Geng,  P Pera,  R J Bernacki
Affiliations

Affiliation

  • 1 Department of Chemistry, State University of New York at Stony Brook, 11794-3400, USA.
PMID: 10617084 DOI: 10.1016/s0960-894x(99)00629-0
Abstract

A series of second-generation taxoids bearing a substituent on the C-2-benzoyl group and modifications at C-3'/C-10 positions was synthesized. These taxoids exhibited 2-3 orders of magnitude higher potency than that of paclitaxel against drug-resistant human breast Cancer cell lines. It is also noteworthy that three taxoids showed almost no difference in activity against drug-resistant and drug-sensitive cell lines, which are categorized as "advanced second generation taxoids".

Figures
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验，部分功能也使用 Cookies 帮助我们更好地理解您的需求，为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问，请阅读我们的《隐私声明》。

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z