2. Academic Validation
  3. Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

  • Bioorg Med Chem Lett. 2000 Jan 3;10(1):39-43. doi: 10.1016/s0960-894x(99)00577-6.
C K Han 1,  S K Ahn,  N S Choi,  R K Hong,  S K Moon,  H S Chun,  S J Lee,  J W Kim,  C I Hong,  D Kim,  J H Yoon,  K T No
Affiliations

Affiliation

  • 1 Chong Kun Dang Research Institute, Chungcheongnamdo, South Korea.
PMID: 10636239 DOI: 10.1016/s0960-894x(99)00577-6
Abstract

New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.

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