2. Academic Validation
  3. Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. II. Physico-chemical properties and structure elucidation

Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. II. Physico-chemical properties and structure elucidation

  • J Antibiot (Tokyo). 2000 Feb;53(2):163-70. doi: 10.7164/antibiotics.53.163.
S Takahashi 1,  T Nakano,  T Koiwa,  T Noshita,  S Funayama,  H Koshino,  A Nakagawa
Affiliations

Affiliation

  • 1 Department of Biosciences, Teikyo University, Utsunomiya, Japan.
PMID: 10805577 DOI: 10.7164/antibiotics.53.163
Abstract

Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing alpha-D-galactose by various NMR spectral analyses and chemical degradation.

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