2. Academic Validation
  3. Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38

Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38

  • Bioorg Med Chem Lett. 2000 May 15;10(10):1029-32. doi: 10.1016/s0960-894x(00)00150-5.
Y Wang 1,  G J Habgood,  W J Christ,  Y Kishi,  B A Littlefield,  M J Yu
Affiliations

Affiliation

  • 1 Eisai Research Institute, Andover, MA 01810, USA.
PMID: 10843209 DOI: 10.1016/s0960-894x(00)00150-5
Abstract

Structurally simplified analogues of halichondrin B were prepared by total synthesis and found to retain potent cell growth inhibitory activity in vitro.

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