2. Academic Validation
  3. A novel pyridazinone derivative as a nonprostanoid PGI2 agonist

A novel pyridazinone derivative as a nonprostanoid PGI2 agonist

  • Bioorg Med Chem Lett. 2000 Dec 18;10(24):2787-90. doi: 10.1016/s0960-894x(00)00571-0.
K Tsubaki 1,  K Taniguchi,  S Tabuchi,  O Okitsu,  K Hattori,  J Seki,  K Sakane,  H Tanaka
Affiliations

Affiliation

  • 1 Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, Osaka, Japan.
PMID: 11133092 DOI: 10.1016/s0960-894x(00)00571-0
Abstract

A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.

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