2. Academic Validation
  3. RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

  • Bioorg Med Chem Lett. 2001 Mar 12;11(5):693-6. doi: 10.1016/s0960-894x(01)00034-8.
A J Collis 1,  M L Foster,  F Halley,  C Maslen,  I M McLay,  K M Page,  E J Redford,  J E Souness,  N E Wilsher
Affiliations

Affiliation

  • 1 Aventis Pharma, Dagenham Research Centre, Essex, UK.
PMID: 11266171 DOI: 10.1016/s0960-894x(01)00034-8
Abstract

Following the discovery of RPR200765, a series of pyrimidine analogues have been prepared as backups. Amongst them, RPR203494 was identified with a better in vitro profile than RPR200765A.

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