2. Academic Validation
  3. 2,4-Thiazolidinediones as potent and selective human beta3 agonists

2,4-Thiazolidinediones as potent and selective human beta3 agonists

  • Bioorg Med Chem Lett. 2001 Mar 26;11(6):757-60. doi: 10.1016/s0960-894x(01)00063-4.
B Hu 1,  J Ellingboe,  I Gunawan,  S Han,  E Largis,  Z Li,  M Malamas,  R Mulvey,  A Oliphant,  F W Sum,  J Tillett,  V Wong
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. hub@war.wyeth.com
PMID: 11277513 DOI: 10.1016/s0960-894x(01)00063-4
Abstract

Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50=0.01 microM, IA=1.19) and selective (more than 110-fold over beta1 and beta2 agonist activity) beta3 agonist. This compound has also been proven to be active and selective in an in vivo mode.

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