2. Academic Validation
  3. Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition

Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition

  • Bioorg Med Chem Lett. 2001 Apr 23;11(8):1019-22. doi: 10.1016/s0960-894x(01)00114-7.
C Michaux 1,  S Rolin,  J M Dogné,  F Durant,  B Masereel,  J Delarge,  J Wouters
Affiliations

Affiliation

  • 1 Lab. Chimie Moleculaire Structurale, Facultés Universitaires N.-D. de la Paix, Namur, Belgium. catherine.michaux@scf.fundp.ac.be
PMID: 11327579 DOI: 10.1016/s0960-894x(01)00114-7
Abstract

BM567, a sulfonylurea compound whose crystal structure is here discussed and terbogrel, are both thromboxane receptor antagonists and thromboxane synthase inhibitors. In this paper, their crystallographic and electronic structures are compared and lead to new synthesis prospects among the sulfonylurea series.

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