2. Academic Validation
  3. Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells

Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells

  • Biosci Biotechnol Biochem. 2001 May;65(5):1211-3. doi: 10.1271/bbb.65.1211.
H Yoshida 1,  T Teramoto,  K Ikeda,  Y Yamori
Affiliations

Affiliation

  • 1 Graduate School of Human and Environmental Studies, Kyoto University, Japan. hyoshida@ip.media.kyoto-u.ac.jp
PMID: 11440142 DOI: 10.1271/bbb.65.1211
Abstract

Glycitein, as one of the three major Isoflavones in soybeans, directly but significantly (about 5%) suppressed the proliferation of MC3T3-E1 and stimulated bone-related protein (Alkaline Phosphatase (ALP) and osteocalcin (OC)) expression. These results indicate that glycitein suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor.

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