2. Academic Validation
  3. Novel 5-vinyl pyrimidine nucleosides with potent anti-hepatitis B virus activity

Novel 5-vinyl pyrimidine nucleosides with potent anti-hepatitis B virus activity

  • Bioorg Med Chem Lett. 2001 Nov 19;11(22):2917-20. doi: 10.1016/s0960-894x(01)00589-3.
R Kumar 1,  D L Tyrrell
Affiliations

Affiliation

  • 1 Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Alberta, Edmonton, Canada T6G 2H7. rakesh.kumar@ualberta.ca
PMID: 11677126 DOI: 10.1016/s0960-894x(01)00589-3
Abstract

Synthesis and Antiviral activities of novel N-1 alkyl substituted pyrimidines, 1-[(2-hydroxyethoxy)methyl]-5-vinyluracil (5), 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-5-vinyluracil (6), and 1-[4-hydroxy-3-(hydroxymethyl)-1-butyl]-5-vinyluracil (7) are reported. Compounds 6 and 7 were potent inhibitors of DHBV in Cell Culture, in contrast, all of the compounds described were devoid of activity against TK(+) HSV-1 and TK(-) HSV-1.

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