1. Academic Validation
  2. Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis

Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis

  • J Antimicrob Chemother. 2002 May;49(5):871-4. doi: 10.1093/jac/dkf007.
Rafael Buitrago-Rey 1 Jorge Olarte Jorge Enrique Gomez-Marin
Affiliations

Affiliation

  • 1 Facultad de Medicina, Universidad Nacional de Colombia, Armenia (Q), Colombia.
Abstract

We examined the effect of an inhibitor of secretory Phospholipase A2 type II (LY311727) and of a specific inhibitor of serine proteases (AEBSF) in a murine model of acute toxoplasmosis. LY311727 did not afford any significant protection and produced earlier mortality compared with untreated mice at a dose of 100 mg/kg. In contrast, AEBSF demonstrated a significant increase in length of survival, and this effect was enhanced when AEBSF was administered with non-protective doses of pyrimethamine.

Figures
Products