2. Academic Validation
  3. Synthesis and evaluation of water-soluble paclitaxel prodrugs

Synthesis and evaluation of water-soluble paclitaxel prodrugs

  • Bioorg Med Chem Lett. 2002 Nov 18;12(22):3301-3. doi: 10.1016/s0960-894x(02)00694-7.
Xia Feng 1,  Ying-Jin Yuan,  Jin-Chuan Wu
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, PR China.
PMID: 12392737 DOI: 10.1016/s0960-894x(02)00694-7
Abstract

A series of water-soluble 2'-paclitaxel prodrugs were synthesized by attaching paclitaxel to polyethylene glycol (PEG) through amino acid spacers. The prodrugs showed highly improved water solubility, enhanced in vitro cytotoxicity and in vivo antitumor activity compared with the native drug, paclitaxel.

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