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  3. Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents

Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents

  • Bioorg Med Chem Lett. 2003 Jan 6;13(1):101-5. doi: 10.1016/s0960-894x(02)00850-8.
Hsing-Pang Hsieh 1,  Jing-Ping Liou,  Ying-Ting Lin,  Neeraj Mahindroo,  Jang-Yang Chang,  Yung-Ning Yang,  Shuenn-Shing Chern,  Uan-Kang Tan,  Chun-Wei Chang,  Tung-Wei Chen,  Chi-Hung Lin,  Ying-Ying Chang,  Chiung-Chiu Wang
Affiliations

Affiliation

  • 1 Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 9F, 161, Sec. 6, Min-Chiuan East Road, Taipei 114, Taiwan, ROC. hphsieh@nhri.org.tw
PMID: 12467626 DOI: 10.1016/s0960-894x(02)00850-8
Abstract

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human Cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

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