2. Academic Validation
  3. Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods

Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods

  • FEMS Microbiol Lett. 2002 Dec 17;217(2):199-205. doi: 10.1111/j.1574-6968.2002.tb11475.x.
Klaus Gebhardt 1,  Judith Schimana,  Johannes Müller,  Hans-Peter Fiedler,  Helmut G Kallenborn,  Meike Holzenkämpfer,  Philipp Krastel,  Axel Zeeck,  Joachim Vater,  Alexandra Höltzel,  Dietmar G Schmid,  Joachim Rheinheimer,  Konrad Dettner
Affiliations

Affiliation

  • 1 Mikrobiologisches Institut, Universität Tübingen, D-72076 Tübingen, Germany.
PMID: 12480104 DOI: 10.1111/j.1574-6968.2002.tb11475.x
Abstract

Endosymbiotic bacteria from the genus Bacillus were isolated from different compartments of the gut of various members of insects (Hexapoda) and millipedes (Diplopoda). They were grown in submerged culture and investigated by biological assays and HPLC-diode array analysis regarding their production of bioactive metabolites, which were isolated and determined in structure. Known compounds and yet unknown derivatives from the primary metabolism were detected, as well as antibacterially and antifungally acting peptide Antibiotics.

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