[Cycloartane triterpenes and glycosides from Cimicifuga acerina]

Aim: To investigate the chemical constituents from the rhizomes of Cimicifuga acerina (Sieb. et Zucc.) Tanaka.

Methods: Column chromatgraphy (including silica gel and ODS) together with HPLC was used to separate the chemical constituents whose structures were determined by FAB-MS, NMR (1D and 2D) and hydrolysis methods.

Results: Five cycloartane triterpenoids were isolated and identified as: (22R)-22-hydroxycimigenol (I), (22R)-22-hydroxy-24-O-acetylhydroshengmanol 3-O-beta-D-xylopyranoside (II), dahurinol (III), 24-epi-24-O-acetyl-7,8-didehydroshengmanol 3-O-beta-D-xylopyranoside (IV), 25-O-acetyl-7,8-didehydrocimigenol 3-O-beta-D-xylopyranoside (V).

Conclusion: Compound I is a new natural product, compound II is a new compound and compounds IV and V were isolated from this plant for the first time.