Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity

We describe the isolation and spectrometric structure elucidation of eight new Xanthones, fuscaxanthone A (1), B (2), C (3), D (4), E (5), F (6), G (7), and H (8), together with eight known Xanthones from the stem bark of Garcinia fusca collected in Thailand. All the new Xanthones were shown to have a terpenoid (prenyl and/or geranyl) side chain(s) in their molecules. We also present the results of a primary screening of the inhibitory effects of eight Xanthones (9-16) isolated as major components of this plant on 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.