2. Academic Validation
  3. Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis

Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis

  • J Nat Prod. 2003 May;66(5):729-31. doi: 10.1021/np030041j.
Yukihiro Asami 1,  Takashi Ogura,  Noboru Otake,  Toshio Nishimura,  Yao Xinsheng,  Takashi Sakurai,  Hiromichi Nagasawa,  Shohei Sakuda,  Kuniaki Tatsuta
Affiliations

Affiliation

  • 1 Department of Biosciences, School of Science and Technology, Teikyo University, 1-1 Toyosatodai, Utsunomiya 320-8551, Japan.
PMID: 12762821 DOI: 10.1021/np030041j
Abstract

A new ellagic acid derivative (1) was isolated from the branches of Combretum yunnanensis, and its structure was assigned as 4-(4' '-O-acetyl-alpha-rhamnopyranosyl)ellagic acid by analysis of its spectral data. Total synthesis of 1 was achieved by the glycosylation of 3,3'-di-O-benzylellagic acid (5) with 4-O-acetyl-2,3-di-O-benzyl-l-rhamnose (4) as a key reaction, and the absolute configuration of 1 was determined. Compound 1 showed weak inhibitory activity against the growth of various tumor cells and inhibited HIV-1 protease.

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