1. Academic Validation
  2. Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors

Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors

  • Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. doi: 10.1016/s0960-894x(03)00434-7.
Jane R Hanrahan 1 Mary Chebib Neil L M Davucheron Belinda J Hall Graham A R Johnston
Affiliations

Affiliation

  • 1 Faculty of Pharmacy, University of Sydney, 2006, Sydney, NSW, Australia. janeh@pharm.usyd.edu.au
Abstract

Amentoflavone is found in a number of Plants with medicinal properties, including Ginkgo biloba and Hypericum perforatum (St. John's Wort). We have developed a rapid and economic semi-synthetic preparation of amentoflavone from Biflavones isolated from autumnal Ginkgo biloba leaves. Several studies have shown that amentoflavone binds to benzodiazepine receptors. Using two electrode voltage-clamp methodology, amentoflavone has been shown to be a negative modulator of GABA at GABA(A) alpha(1)beta(2)gamma(2L) receptors expressed in Xenopus laevis oocytes This action appears to be independent of the flumazenil-sensitive benzodiazepine modulatory sites on the GABA(A) receptor.

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