2. Academic Validation
  3. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase

Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase

  • Arch Pharm Res. 2003 Sep;26(9):735-8. doi: 10.1007/BF02976684.
Dae Keun Kim 1,  Kieseung Lee
Affiliations

Affiliation

  • 1 College of Pharmacy, Woosuk University, Samrye 565-701, Korea. dkkim@woosuk.ac.kr
PMID: 14560923 DOI: 10.1007/BF02976684
Abstract

The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an Enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-coumaroyl tyramine, as an inhibitor on AChE. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of trans-N-p-coumaroyl tyramine was 34.5 microg/mL (122 microM).

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