2. Academic Validation
  3. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. II. Structure elucidation

Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. II. Structure elucidation

  • J Antibiot (Tokyo). 1992 Dec;45(12):1899-906. doi: 10.7164/antibiotics.45.1899.
A A Tymiak 1,  H A Ax,  M S Bolgar,  A D Kahle,  M A Porubcan,  N H Andersen
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000.
PMID: 1490881 DOI: 10.7164/antibiotics.45.1899
Abstract

Fermentation of Dactylosporangium sp. (ATCC 53693) produces a mixture of Tetracycline derivatives from which several related Tetracycline glycosides, the dactylocyclines, were isolated and their structures determined. The most abundant glycoside in initial fermentations was found to be dactylocycline A. Each glycoside proved to be acid sensitive and readily hydrolyzed to a common aglycone, dactylocyclinone. While the aglycone was cross resistant with Tetracycline, the dactylocyclines proved active against certain tetracycline-resistant organisms.

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