2. Academic Validation
  3. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

  • Proc Natl Acad Sci U S A. 2004 May 18;101(20):7681-6. doi: 10.1073/pnas.0402293101.
Yanan Zhu 1,  Bradley J Swanson,  Michael Wang,  David A Hildeman,  Brian C Schaefer,  Xinqi Liu,  Hiroyuki Suzuki,  Katsuyoshi Mihara,  John Kappler,  Philippa Marrack
Affiliations

Affiliation

  • 1 Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
PMID: 15136728 DOI: 10.1073/pnas.0402293101
Abstract

Apoptosis in activated T cells in vivo requires the proapoptotic Bcl-2 Family member Bim. We show here that, despite its ability to bind LC8, a component of the microtubule dynein motor complex, most of the Bim in both healthy and apoptotic T cells is associated with mitochondria, not microtubules. In healthy resting T cells Bim is bound to the antiapoptotic proteins Bcl-2 and Bcl-x(L). In activated T cells, levels of Bcl-2 fall, and Bim is associated more with Bcl-x(L) and less with Bcl-2. Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 Family members on mitochondria rather than by sequestration to the microtubules.

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