1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family

Bcl-2 Family (Bcl-2蛋白家族)

Bcl-2 是一个进化相关的蛋白质家族。这些蛋白质控制线粒体外膜通透性 (MOMP),可以是促凋亡的(Bax、Bad、Bak 和 Bok 等),也可以是抗凋亡的(包括 Bcl-2 本身、Bcl-xL 和 Bcl-w 等)。迄今为止,Bcl-2 家族中已知的基因共有 25 个。编码属于该家族的蛋白质的人类基因包括:Bak1、Bax、Bal-2、Bok、Mcl-1。

Bcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, Bad, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date. Human genes encoding proteins that belong to this family include: Bak1, Bax, Bal-2, Bok, Mcl-1.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15531
    Venetoclax

    维奈妥拉

    Inhibitor 99.95%
    Venetoclax (ABT-199; GDC-0199) 是一种高效,有选择性和口服有效的 Bcl-2 抑制剂,Ki 小于0.01 nM。Venetoclax 可以诱导自噬 (autophagy) 作用。
    Venetoclax
  • HY-10087
    Navitoclax

    生根粉263

    Inhibitor 99.97%
    Navitoclax (ABT-263) 是一种口服有效的 Bcl-2 抑制剂,可与 Bcl-xLBcl-2Bcl-w 等多种 Bcl-2 家族蛋白结合,Ki 值小于 1 nM。
    Navitoclax
  • HY-107202
    Polyinosinic-polycytidylic acid 99.40%
    Polyinosinic-polycytidylic acid (Poly(I:C)) 是双链 RNA 的合成类似物,是一种 TLR3 和视黄酸诱导型基因 I 受体 (RIG-IMDA5) 的激动剂。Polyinosinic-polycytidylic acid 可以用作疫苗佐剂,以增强先天性和适应性免疫反应,并改变肿瘤的微环境,还可以直接触发癌细胞发生凋亡 (apoptosis)。
    Polyinosinic-polycytidylic acid
  • HY-13755
    Sulforaphane

    萝卜硫素

    Inhibitor 99.75%
    Sulforaphane 是一种具有口服活性的 Keap1/Nrf2/ARE 诱导剂。Sulforaphane 能促进肿瘤抑制蛋白的转录,并有效地抑制 HDACs 的活性。Sulforaphane 通过激活 Keap1/Nrf2/ARE 途径,以及进一步诱导 HO-1 的表达保护心脏。Sulforaphane 通过 AMPK 依赖性信号传导抑制高糖诱导的胰腺癌。Sulforaphane 具有抗癌和抗炎活性。
    Sulforaphane
  • HY-50907
    ABT-737 Inhibitor 99.96%
    ABT-737 是一种 BH3 模拟物,是一种有效的 Bcl-2Bcl-xLBcl-w 抑制剂,EC50 分别为 30.3 nM、78.7 nM 和 197.8 nM。ABT-737 诱导 BCL-2/BAX 复合物的破坏和 BAK 依赖性但不依赖 BIM 的内在凋亡途径激活。ABT-737 诱导自噬,并且具有用于急性髓系白血病 (AML) 研究的潜力。
    ABT-737
  • HY-N6615
    Aflatoxin B1

    黄曲霉毒素B1

    99.96%
    Aflatoxin B1 (AFB1) 是一种 1A 类致癌物质,是由 Aspergillus flavusA. parasiticus 产生的次级代谢产物。Aflatoxin B1 主要通过在抑癌基因 p53 的密码子 249 的第三位引发 G 到 T 的转换,从而导致突变。在体内,Aflatoxin B1 可引起肠道和肾脏损伤,并具有一定的致畸作用。
    Aflatoxin B1
  • HY-169925
    BM-962 Inhibitor
    BM-962 (Compound 31) 是一种有效的小分子抑制剂,对 Bcl-2IC0 值为 4 nM (Ki=0.8 nM), 对 Bcl-xLIC50 值为 3.9 nM (Ki <1 nM)。BM-962 对 H1417 和 H146 细胞系有抑制作用,IC50 值分别为 9 和 13 nM。BM-962 有望用于癌症研究。
    BM-962
  • HY-N0905
    Ginsenoside Rh4

    人参皂苷Rh4

    Activator 99.28%
    Ginsenoside Rh4 是从 Panax notoginseng 中获得的稀有皂苷。Ginsenoside Rh4 激活 Baxcaspase 3caspase 8caspase 9。Ginsenoside Rh4 还诱导自噬。
    Ginsenoside Rh4
  • HY-100741
    S63845 Inhibitor 99.94%
    S63845 是一种有效的选择性骨髓细胞白血病 1 (MCL1) 抑制剂,结合人 MCL1Kd 值为 0.19 nM。
    S63845
  • HY-19741
    A-1331852 Inhibitor 99.93%
    A-1331852是具有口服活性的BCL-XL选择性抑制剂,Ki值小于10 pM。
    A-1331852
  • HY-13594
    Chlorin e6 98.31%
    Chlorin e6 是一种光敏剂,在波长 402 和 662 nm 处有较强的吸收峰,在 668 nm 处表现出强烈的荧光。Chlorin e6 具有抗菌功效和抗癌活性。Chlorin e6 通过激活 caspase-3 诱导细胞凋亡,可用于癌症的研究。
    Chlorin e6
  • HY-103269
    BAI1 Inhibitor 99.89%
    BAI1 是一种选择性的凋亡因子 BAX 变构抑制剂。BAI1 结合 BAX 并变构抑制其激活。BAI1 具有潜力用于 BAX 依赖性细胞死亡介导的疾病的研究。
    BAI1
  • HY-114855
    BT2 Inhibitor 99.81%
    BT2 是 BCKDC 激酶 (BDK) 抑制剂,IC50 值为 3.19 μM。BT2 与 BDK 的结合会触发支链 α-酮酸脱氢酶复合物 (BCKDC) 的 N 末端结构域的螺旋运动,从而导致 BDK 与 BCKDC 分离。BT2 (compound 4) 也是一种有效的选择性的 Mcl-1 抑制剂,Ki 值为 59 μM。
    BT2
  • HY-101533
    AZD-5991 Inhibitor 99.79%
    AZD-5991 是一种有效的选择性 Mcl-1 抑制剂,FRET 实验检测的 IC50 为 0.7 nM, SPR 实验检测的 Kd 为 0.17 nM。
    AZD-5991
  • HY-19725
    A-1155463 Inhibitor 99.60%
    A-1155463是高效选择性的 BCL-XL 抑制剂,在Molt-4细胞中的EC50值为70 nM。
    A-1155463
  • HY-B0402
    Amantadine

    金刚烷胺

    Modulator 99.90%
    Amantadine (1-Adamantanamine) 是一种口服有效的抗甲型流感 (influenza A) 病毒的抗病毒剂。Amantadine 对 NMDAM2 等多种离子通道均有抑制作用。Amantadine 还具有抗正痘病毒 (orthopoxvirus) 和抗癌活性。Amantadine 可用于帕金森病,术后认知功能障碍 (POCD) 和 COVID-19 的研究。
    Amantadine
  • HY-B1192
    Estradiol benzoate

    苯甲酸雌二醇

    99.89%
    Estradiol benzoate (β-Estradiol 3-benzoate) 是一种 HBx蛋白 的抑制剂,抑制雄激素和乙型肝炎病毒(HBV) 的转录,复制。Estradiol benzoate 具有抗生育作用和抗弓形虫活性并且能够改善 Ovx 雌性小鼠的记忆行为。
    Estradiol benzoate
  • HY-130604
    DT2216 Degrader 99.97%
    DT2216 是一种 PROTAC 类的有效的,选择性的 BCL-XL (Bcl-2 家族成员) 降解剂。DT2216 通过募集 Von Hippel-Lindau (VHL) E3 泛素连接酶来降解 BCR-ABL 蛋白。DT2216 可以抑制各种 BCL-XL 依赖性白血病和癌细胞,但对血小板的毒性要小得多。DT2216 由 Bcl-2 家族蛋白抑制剂 Navitoclax (HY-10087)、linker 和 VHL E3 泛素连接酶组成 (Red: Navitoclax; Blue: VHL ligand; Black: linker)。
    DT2216
  • HY-B1135
    Benzbromarone

    苯溴马隆

    99.81%
    Benzbromarone 是一种具有口服活性的抗痛风剂。Benzbromarone 具有抗炎、抗氧化应激和肾保护作用,可用于高尿酸血症和痛风的研究。
    Benzbromarone
  • HY-112218
    MIK665 Inhibitor 99.11%
    MIK665 (S-64315) ,源于 S63845,是一种髓系细胞白血病序列1 (MCL1) 抑制剂,对 MCL1 的 IC50 为 1.81 nM。
    MIK665
目录号 产品名 / 同用名 应用 反应物种

Bcl-2 family members have been grouped into three classes. The anti-apoptotic subfamily contains the Bcl-2, Bcl-XL, Bcl-w, Mcl-1, Bfl1/A-1, and Bcl-B proteins, which suppress apoptosis and contain all four Bcl-2 homology domains, designated BH1-4. The pro-apoptotic subfamily contain BH1-3 domains, such as Bax, Bak, and Bok. A third class of BH3 only proteins Bad, Bid, Bim, Noxa and Puma have a conserved BH3 domain that can bind and regulate the anti-apoptotic BCL-2 proteins to promote apoptosis [1].


The intrinsic pathway is initiated by various signals, principally extracellular stimuli. BH3-only proteins (Bim, Bid, Bad, Noxa, Puma) engage with anti-apoptotic Bcl-2 family proteins to relieve their inhibition of Bax and Bak to activate them. Next, Bax and Bak are oligomerized and activated, leading to mitochondrial outer membrane permeabilization. Once mitochondrial membranes are permeabilized, cytochrome c and/or Smac/DIABLO is released into the cytoplasm, wherein they combine with an adaptor molecule, Apaf-1, and an inactive initiator Caspase, Pro-caspase 9, within a multiprotein complex called the apoptosome. Smac/DIABLO inhibits IAPs to activate Caspase 9. Caspase 9 activates Caspase 3, which is the initiation step for the cascade of Caspase activation. The extrinsic pathway can be activated by cell surface receptors, such as Fas and TNF Receptor, subsequently activating Caspase 8, and leads to Caspase 3 activation and cell demolition. Caspases in turn cleave a series of substrates, activate DNases and orchestrate the demolition of the cell. Bcl-2 family proteins are also found on the endoplasmic reticulum and the perinuclear membrane in hematopoietic cells, but they are predominantly localized to mitochondria [2]

 

Reference:
[1]. Cotter TG, et al. Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer. 2009 Jul;9(7):501-7.

[2]. Kang MH, et al. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 2009 Feb 15;15(4):1126-32.

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

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Please try each isoform separately.

Bcl-2 Family (Bcl-2蛋白家族) Degraders, Inducers, Inhibitors, Agonists, Antagonists, Activators & Modulators
Product NameBcl-2Bcl-xLBcl-WMcl-1Bfl-1Bcl-BBaxBakBimPurity    
Venetoclax
Bcl-2, Ki: 0.01 nM
Bcl-xL, Ki: 48 nM
Bcl-W, Ki: 245 nM
      99.95%
Navitoclax
Bcl-2, Ki: 1 nM
Bcl-xL, Ki: 1 nM
Bcl-W, Ki: 1 nM
      99.97%
Polyinosinic-polycytidylic acid
Bcl-2
     
Bax
  99.40%
Sulforaphane      
Bax
  99.75%
ABT-737
Bcl-2, EC50: 30.3 nM
Bcl-xL, EC50: 78.7 nM
Bcl-W, EC50: 197.8 nM
Mcl-1, EC50: >10 μM
Bfl-1, EC50: >10 μM
Bcl-B, EC50: 1820 nM
   99.96%
Ginsenoside Rh4      
Bax
  99.28%
S63845   
MCL1, Kd: 0.19 nM
     99.94%
A-1331852
Bcl-2, Ki: 6 nM
Bcl-xL, Ki: 0.01 nM
Bcl-W, Ki: 4 nM
Mcl-1, Ki: 142 nM
     99.93%
Chlorin e6
Bcl-2
     
Bax
  98.31%
BAI1      
Bax
  99.89%
BT2   
Mcl-1, Ki: 59 μM
     99.81%
AZD-5991   
Mcl-1, IC50: 0.7 nM
Mcl-1, Kd: 0.17 nM
     99.79%
A-1155463
Bcl-2, Ki: 80 nM
Bcl-xL, Ki: 0.01 nM
       99.60%
Amantadine
Bcl-2
     
Bax
  99.90%
Estradiol benzoate      
Bax
  99.89%
Benzbromarone
Bcl-2
        99.81%
MIK665   
Mcl-1, IC50: 1.81 nM
     99.11%
Obatoclax Mesylate
Bcl-2, Ki: 220 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
   99.74%
Digitoxin
Bcl-2
     
Bax
  99.36%
Dehydrocorydaline
Bcl-2
     
Bax
  99.77%
Gossypol
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
       99.67%
WEHI-539 hydrochloride 
Bcl-xL, IC50: 1.1 nM
       99.72%
AZD4320
BCL2, IC50: 17 nM (KPUM-UH1 cells)
BCLxL, IC50: 17 nM (KPUM-UH1 cells)
       99.68%
Bax inhibitor peptide V5      
Bax
  99.77%
Gambogic Acid
Bcl-2, IC50: 1.21 μM
Bcl-xL, IC50: 1.47 μM
Bcl-W, IC50: 2.02 μM
Mcl-1, IC50: 0.79 μM
Bfl-1, IC50: 1.06 μM
Bcl-B, IC50: 0.66 μM
   98.79%
Dihydrocapsaicin
Bcl-2
Bcl-xL
    
Bax
  99.93%
A-1210477
Bcl-2, Ki: 132 nM
 
Bcl-W, Ki: 2280 nM
Mcl-1, Ki: 0.45 nM
Bfl-1, Ki: 660 nM
    99.40%
UMI-77
Bcl-2, Ki: 23.83 μM
Bcl-xL, Ki: 32.99 μM
Bcl-W, Ki: 8.19 μM
Mcl-1, Ki: 0.49 μM
Bfl-1, Ki: 5.33 μM
    99.66%
Tapotoclax   
Mcl-1, Ki: 0.13 nM
     99.53%
Hydralazine hydrochloride
Bcl-2
Bcl-xL
       99.97%
Gossypol (acetic acid)
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
       99.75%
AVN-944      
Bax
Bak
 99.77%
PROTAC Mcl1 degrader-1
Bcl-2, IC50: 0.54 μM
  
Mcl-1, IC50: 0.78 μM
     98.13%
Lisaftoclax
Bcl-2, IC50: 2 nM
Bcl-xL, IC50: 5.9 nM
       99.28%
Peiminine
Bcl-2
        99.94%
AS 1411
Bcl-2
        
BTSA1      
Bax, IC50: 250 nM
Bax, EC50: 144 nM
  99.49%
MSN-125      
Bax
Bak
 99.00%
Amantadine hydrochloride
Bcl-2
     
Bax
  ≥98.0%
Paris saponin VII
Bcl-2
        99.96%
Triclabendazole
Bcl-2
     
Bax
  98.72%
Bz 423      
Bax
Bak
 99.72%
PROTAC Bcl2 degrader-1
Bcl-2, DC50: 3 μM
Bcl-2, IC50: 4.94 μM
  
Mcl-1, IC50: 11.81 μM
     99.80%
Deltamethrin
Bcl-2
     
Bax
  99.93%
(R)-Sulforaphane      
Bax
  99.48%
TCPOBOP
Bcl-2
        98.67%
Bim-IN-1        
Bim
99.57%
(E)-Ferulic acid      
Bax
  99.89%
TC11   
MCL1
     98.04%
Pyraclostrobin
Bcl-2
     
Bax
  99.91%
Navitoclax-piperazine 
Bcl-xL
       99.73%
S55746
Bcl-2, Ki: 1.3 nM
Bcl-2, Kd: 3.9 nM
Bcl-xL, Ki: 520 nM
Bcl-xL, Kd: 186 nM
       99.89%
CLZ-8   
Mcl-1, Ki: 0.3 μM
     99.85%
Humanin      
Bax
  99.83%
TW-37
Bcl-2, Ki: 290 nM
Bcl-xL, Ki: 1110 nM
 
Mcl-1, Ki: 260 nM
     99.27%
(R)-(-)-Gossypol acetic acid
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
     98.93%
PROTAC Bcl-xL degrader-2 
Bcl-xL, IC50: 0.6 nM
       98.16%
Sabutoclax
BCL2, IC50: 0.32 μM
Bcl-xL, IC50: 0.31 μM
 
Mcl-1, IC50: 0.2 μM
Bfl-1, IC50: 0.62 μM
    99.80%
XZ739 
Bcl-xL, DC50: 2.5 nM
       99.06%
Jaceosidin      
Bax
  99.51%
VU0661013   
Mcl-1
     98.45%
Maritoclax   
Mcl-1, IC50: 10.1 μM
     99.97%
BM-1197
Bcl-2, IC50: 3.5 nM
Bcl-xL, IC50: 5.2 nM
       99.48%
L6H21
Bcl-2
     
Bax
  99.46%
MSN-50      
Bax
Bak
 98.68%
(R)-(-)-Gossypol
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
     98.82%
HA14-1
Bcl-2, IC50: 9 μM
        ≥98.0%
Isolinderalactone
Bcl-2
        98.79%
ML311   
Mcl-1
    
Bim
98.98%
Pyridoclax   
Mcl-1
     99.95%
PUMA BH3       
Bak, Kd: 26 nM
 98.24%
BAM7      
Bax, IC50: 3.3 μM
  98.53%
A-385358
Bcl-2, Ki: 67 nM
Bcl-xL, Ki: 0.8 nM
       98.19%
Murizatoclax   
MCL1, Ki: 15 pM
     98.85%
MCL-1/BCL-2-IN-1
Bcl-2, IC50: 3.18 μM
  
Mcl-1, IC50: 4.45 μM
     99.86%
Aspidin BB
Bcl-2
     
Bax
  98.08%
BAX-IN-1      
Bax
  ≥98.0%
MIM1   
Mcl-1
     ≥98.0%
GL0388      
Bax
  98.01%
BH3I-1
Bcl-2
Bcl-xL
     
Bak
Bim
≥98.0%
Mcl-1 inhibitor 6
Bcl-2, Kd: >10 μM
Bcl2A1, Kd: >10 μM
Bcl-2, Ki: 10 μM
Bcl-xL, Kd: >10 μM
Bcl-W, Kd: >10 μM
Mcl-1, Kd: 0.23 nM
Mcl-1, Ki: 0.02 μM
Bfl-1, Ki: 1.57 μM
    98.40%
Thevetiaflavone
Bcl-2
     
Bax
  ≥98.0%
Destruxin B
Bcl-2
        99.86%
Bax activator-1      
Bax
  98.45%
PZ703b 
Bcl-xL
       98.47%
S55746 hydrochloride
Bcl-2, Ki: 1.3 nM
Bcl-2, Kd: 3.9 nM
Bcl-xL, Ki: 520 nM
Bcl-xL, Kd: 186 nM
       99.66%
AZD-5991 (S-enantiomer)   
Mcl-1, IC50: 6.3 μM
Mcl-1, Kd: 0.98 μM
     99.83%
Bfl-1-IN-2    
Bfl-1, IC50: 4.3 μM
    99.76%
MNK8
Bcl-2
        99.76%
Obatoclax
BCL2, Ki: 200 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
   ≥99.0%
IMB-XH1   
Mcl-1
     ≥98.0%
(+)-Apogossypol
Bcl-2, EC50: 2.8 μM
Bcl-xL, EC50: 3.69 μM
 
Mcl-1, EC50: 2.6 μM
     
n-Butyl-β-D-fructofuranoside
Bcl-2
     
Bax
  
(S)-Gossypol (acetic acid)
Bcl-2
Bcl-xL
       98.39%
PZ703b TFA 
Bcl-xL
       98.62%
Mcl1-IN-1   
Mcl-1, IC50: 2.4 μM
     98.40%
WEHI-539 
Bcl-xL, IC50: 1.1 nM
       
Mcl1-IN-9   
Mcl-1, Ki: 0.03 nM
     
Bcl-2-IN-2
Bcl-2, IC50: 0.034 nM
Bcl-xL, IC50: 43 nM
       
Mcl-1 inhibitor 3   
Mcl-1, IC50: 19 nM
Mcl-1, Ki: 0.061 nM
     
Apogossypolone
Bcl-2, Ki: 35 nM
Bcl-xL, Ki: 660 nM
 
Mcl-1, Ki: 25 nM
     
(E)-Mcl-1 inhibitor 7   
Mcl-1, Ki: <10 nM
Mcl-1, IC50: <500 nM
     
Amantadine sulfate
Bcl-2
     
Bax
  
BPA-B9
Bcl-2
  
Mcl-1
     
BCL-XL-IN-3 
BCLxL, Ki: <0.01 nM
       
Aviculin
Bcl-2
     
Bax
  
PROTAC Bcl-xL degrader-3 
Bcl-xL
       
Astin B
Bcl-2
     
Bax
  
Mcl-1 inhibitor 12   
Mcl-1, Ki: 0.22 nM
     
Apoptosis inducer 19
Bcl-2
     
Bax
  
SMBA1      
Bax, Ki: 43.3 nM
  
Bcl-2-IN-7
Bcl-2
     
Bax
  
Spicamycin
Bcl-2
        
JNJ-4355   
Mcl-1, Ki: 18 pM
     
Apoptotic agent-3
Bcl-2
     
Bax
  
Antitumor agent-77
Bcl-2
     
Bax
  
anti-TNBC agent-3
Bcl-2
        
BM-1074
Bcl-2, IC50: 1.8 nM
Bcl-xL, IC50: 6.9 nM
       
Antitumor agent-78
Bcl-2
     
Bax
  
Anticancer agent 63
Bcl-2
        
Dehydrobruceine B
Bcl-2
Bcl-xL
    
Bax
  
Bcl-2/Mcl-1-IN-2
Bcl-2, Ki: 4.70 μM
  
Mcl-1, Ki: 0.88 μM
     
Bcl-2-IN-9
Bcl-2, IC50: 2.9 μM ([1])
        
Topoisomerase I inhibitor 17
Bcl-2
     
Bax
  
Bcl-2-IN-4
Bcl-2, IC50: 1.5 nM
Bcl-xL, IC50: 411 nM
       
Mcl-1 inhibitor 13   
Mcl-1, Ki: 8.2 nM
     
Bcl-2/Mcl-1-IN-3
Bcl-2, Ki: 0.23 μM
Bcl-xL, Ki: 15 μM
 
Mcl-1, Ki: 0.14 μM
     
Bcl-2/Mcl-1-IN-1
Bcl-2, Ki: 4.53 μM
  
Mcl-1, Ki: 1.19 μM
     
PROTAC Bcl-xL degrader-1 
Bcl-xL
       
Anticancer agent 201
Bcl-2
Bcl-xL
       
Bcl-2-IN-5
Bcl-2, IC50: 0.12 nM
        
CDK1/2/4-IN-1
Bcl-2
     
Bax
  
Apoptotic agent-2
Bcl-2
     
Bax
  
Jaceosidin (Standard)      
Bax
  
CYD-4-61      
Bax
  
Anticancer agent 65
Bcl-2
     
Bax
  
PZ703b hydrochloride 
Bcl-xL
       99.18%
KRN5500
Bcl-2
        
GQN-B37-E   
Mcl-1, Ki: 0.6 μM
     
Bcl-2/Mcl-1-IN-4
Bcl-2, Ki: 0.49 μM
  
Mcl-1, Ki: 0.51 μM
     
EGFR-IN-109
Bcl-2
     
Bax
  
Anticancer agent 43      
Bax
  98.58%
BBR-BODIPY      
Bax
  98.15%
Furowanin A   
Mcl-1
     
EGFR-IN-134
Bcl-2
     
Bax
  
HSP70-IN-6        
Bim
BDA-366
Bcl-2, Ki: 3.3 nM
        
TRP-601
Bcl-2
        
Bcl-2-IN-6
Bcl-2
     
Bax
  
LSD1-IN-26
Bcl-2
        
Lobetyol
Bcl-2
     
Bax
  
Bcl-2-IN-11
Bcl-2, IC50: 0.9 nM
Bcl-xL, IC50: >1000 nM
       
BRD4 Inhibitor-15
Bcl-2
     
Bax
  
PUMA BH3 TFA       
Bak, Kd: 26 nM
 
Anticancer agent 64
Bcl-2
     
Bax
  
Bcl-2-IN-10      
Bax
  
A09-003   
Mcl-1
     
YC137
Bcl-2, Ki: 1.3 μM
Bcl-xL, Ki: >100 μM
       
8α-Tigloyloxyhirsutinolide 13-O-acetate
Bcl-2
Bcl-xL
 
Mcl-1
     
YCW-E11
Bcl-2
  
Mcl-1
     
TM-233   
Mcl-1
     
MLS-0053105
Bcl-2/F-Bim, IC50: 12.5 μM
Bcl-XL/F-Bim, IC50: 50 μM
Bcl-W/F-Bim, IC50: 12.5 μM
 
Bfl-1/F-Bid, IC50: 0.4 μM
    
Bcl-2-IN-3
Bcl-2
        
Thaspine acetate      
Bax
Bak
 
Bax agonist 1      
Bax, Ki: 57.2 nM
  
(-)BI97D6
Bcl-2, IC50: 0.031 μM
Bcl-xL, IC50: 0.076 μM
 
Mcl-1, IC50: 0.025 μM
     
AZD-5991 Racemate   
Mcl-1, IC50: 3 nM
     
BM 957
Bcl-2, IC50: 5.4 nM
Bcl-2, Ki: 1.2 nM
Bcl-xL, IC50: 6.0 nM
Bcl-xL, Ki: <1 nM
       
Bak BH3 
Bcl-xL
       
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