2. Academic Validation
  3. Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum

Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum

  • Bioorg Med Chem. 2004 Jul 15;12(14):3885-9. doi: 10.1016/j.bmc.2004.05.007.
Ji Ma 1,  Shannon H Jones,  Sidney M Hecht
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Virginia, Charlottesville, VA, 22901, USA.
PMID: 15210155 DOI: 10.1016/j.bmc.2004.05.007
Abstract

In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu(2+). Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N-cis-feruloyl tyramine (1),N-trans-feruloyl tyramine (2), and 1-cinnamoylpyrrolidine (3). Compounds 1-3 represent a structurally new type of DNA strand scission agent.

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